Department of Hygiene and Preventive Medicine, Iwate Medical University
Department of Nursing Informatics, Graduate School of Nursing Science, St. Luke’s International University
Department of Health Science, Kyoto Prefectural University
Faculty of Humanities and Social Sciences, Iwate University
Department of Health Food Sciences, University of Human Arts and Sciences
Department of Hygiene and Preventive Medicine, Iwate Medical University
Iwate Prefectural Advanced Critical Care and Emergency Center, Iwate Medical University
Health Care Center, Iwate University
Department of Internal Medicine, Morioka Tsunagi Onsen Hospital
Department of Neurosurgery, Iwate Medical University
Division of Nephrology and Hypertension, Department of Internal Medicine, Iwate Medical University
Division of Nephrology and Hypertension, Department of Internal Medicine, Iwate Medical University
Stroke Center, Division of Neurology and Gerontology, Department of Internal Medicine, Iwate Medical University
Division of Hematology and Oncology, Department of Internal Medicine, Iwate Medical University
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University
Department of Information Science, Iwate Medical University
Iwate Health Service Association
Center for Liberal Arts and Sciences, Department of Human Sciences, Iwate Medical University
Department of Hygiene and Preventive Medicine, Iwate Medical University
Department of Hygiene and Preventive Medicine, Iwate Medical University
Department of Hygiene and Preventive Medicine, Iwate Medical University
Department of Hygiene and Preventive Medicine, Iwate Medical University
Department of Hygiene and Preventive Medicine, Iwate Medical University, The Research Institute of Strategy for Prevention
登録日
2021-12-23
雑誌名
Nutrients
巻
13
号
11
ページ
3781
発行年
2021-10-25
ISSN
20726643
抄録
We aimed to evaluate the association between the milk consumption and incident stroke in a Japanese population, where milk consumption is lower than that of Western countries. In total, 14,121 participants (4253 men and 9868 women) aged 40–69 years, free from cardiovascular diseases (CVD) were prospectively followed for 10.7 years. Participants were categorized into four groups according to the milk intake frequency obtained from a brief-type self-administered diet questionnaire. The adjusted HRs of total stroke, ischemic stroke and haemorrhagic stroke associated with milk intake frequency were calculated using the Cox proportional hazards model. During the follow-up, 478 stroke cases were detected (208 men and 270 women). Compared to women with a milk intake of <2 cups/week, those with an intake of 7 to <12 cups/week had a significantly low risk of ischemic stroke in a model adjusting CVD risk factors; the HR (95% CI) was 0.53 (0.32–0.88). No significant associations were found in men. This study suggested that milk intake of 7 to <12 cups/week decreased the risk of ischemic stroke in Japanese women. Milk intake of about 1 to <2 cups/day may be effective in the primary prevention of ischemic stroke in a population with low milk intake