Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
Cryobiofrontier Research Center, Faculty of Agriculture, Iwate University
Cryobiofrontier Research Center, Faculty of Agriculture, Iwate University
National Institute of Agrobiological Sciences
Research Institute of Bio-system Infomatics, Tohoku Chemical Co., Ltd.
Department of Life Science, Faculty of Bioresources, Mie University
Department of Life Science, Faculty of Bioresources, Mie University
Division of Hematology and Oncology, Internal Medicine, Iwate Medical University School of Medicine
Division of Hematology and Oncology, Internal Medicine, Iwate Medical University School of Medicine
Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
登録日
2010-10-05
雑誌名
Peptides
巻
31
号
5
ページ
827 - 833
発行年
2010-05-01
ISSN
0196-9781
Abstract
A palmitoyl conjugate of an insect pentapeptide that occurs in diapausing insects causes a reversible cell-cycle arrest and suppresses mitochondrial respiration. This peptide compound also causes growth arrest in murine leukemic cell line expressing human gene Bcr/Abl and a farnesoyl peptide induces embryonic diapause in Bombyx mori. These results demonstrate that the insect peptide compounds can lead to the understanding of a common pathway in developmental arrest in animals and may provide a new peptidominetic analog in the development of biopharmaceuticals and pest management.
A palmitoyl conjugate of insect pentapeptide Yamamarin arrests cell proliferation and respiration
Peptides-v31n5p827-833.pdf
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