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Characterization of microRNA expression in B cells derived from Japanese black cattle naturally infected with bovine leukemia virus by deep sequencing
https://iwate-u.repo.nii.ac.jp/records/15772
https://iwate-u.repo.nii.ac.jp/records/1577274e30c7c-477f-4fcb-ae02-bc1b4bfa3698
名前 / ファイル | ライセンス | アクション |
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ploso-v19n9pe0256588 (1.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-08-26 | |||||
タイトル | ||||||
タイトル | Characterization of microRNA expression in B cells derived from Japanese black cattle naturally infected with bovine leukemia virus by deep sequencing | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
OCHIAI, Chihiro
× OCHIAI, Chihiro× MIYAUCHI, Sonoko× KUDO, Yuta× NARUKE, Yuta× YONEYAMA, Syuji× TOMITA, Keisuke× DONGZE, Leng× CHIBA, Yusuke× HIRATA, To-Ichi× ICHIJO, Toshihiro× NAGAI, Kazuya× KOBAYASHI, Sota× YAMADA, Shinji× HIKONO, Hirokazu× MURAKMI, Kenji |
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著者(機関) | ||||||
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University , Food Safety and Consumer Affairs Bureau, Ministry of Agriculture, Forestry and Fisheries | ||||||
著者(機関) | ||||||
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University , Department of Agriculture, Forestry and Fisheries, Ehime Prefectural Government | ||||||
著者(機関) | ||||||
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University , Department of Agriculture, Forestry and Fisheries, Iwate Prefectural Government | ||||||
著者(機関) | ||||||
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University | ||||||
著者(機関) | ||||||
Graduate School of Veterinary Sciences, Iwate University | ||||||
著者(機関) | ||||||
Graduate School of Veterinary Sciences, Iwate University | ||||||
著者(機関) | ||||||
Graduate School of Veterinary Sciences, Iwate University | ||||||
著者(機関) | ||||||
Graduate School of Veterinary Sciences, Iwate University | ||||||
著者(機関) | ||||||
Field Science Center, Faculty of Agriculture, Iwate University | ||||||
著者(機関) | ||||||
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University | ||||||
著者(機関) | ||||||
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University | ||||||
著者(機関) | ||||||
Division of Bacterial and Parasitic Disease, National Institute of Animal Health | ||||||
著者(機関) | ||||||
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University , Graduate School of Veterinary Sciences, Iwate University | ||||||
著者(機関) | ||||||
Department of Animal Sciences, Teikyo University of Science | ||||||
著者(機関) | ||||||
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University , Graduate School of Veterinary Sciences, Iwate University | ||||||
登録日 | ||||||
日付 | 2022-08-26 | |||||
書誌情報 |
PLoS ONE 巻 16, 号 9, p. e0256588, 発行日 2021-09-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19326203 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis (EBL), a malignant B cell lymphoma. However, the mechanisms of BLV-associated lymphomagenesis remain poorly understood. Here, after deep sequencing, we performed comparative analyses of B cell microRNAs (miRNAs) in cattle infected with BLV and those without BLV. In BLV-infected cattle, BLV-derived miRNAs (blv-miRNAs) accounted for 38% of all miRNAs in B cells. Four of these blv-miRNAs (blv-miR-B1-5p, blv-miR-B2-5p, blv-miR-B4-3p, and blv-miR-B5-5p) had highly significant positive correlations with BLV proviral load (PVL). The read counts of 90 host-derived miRNAs (bta-miRNAs) were significantly down-regulated in BLV-infected cattle compared to those in uninfected cattle. Only bta-miR-375 had a positive correlation with PVL in BLV-infected cattle and was highly expressed in the B cell lymphoma tissue of EBL cattle. There were a few bta-miRNAs that correlated with BLV tax/rex gene expression; however, BLV AS1 expression had a significant negative correlation with many of the down-regulated bta-miRNAs that are important for tumor development and/or tumor suppression. These results suggest that BLV promotes lymphomagenesis via AS1 and blv-miRNAs, rather than tax/rex, by down-regulating the expression of bta-miRNAs that have a tumor-suppressing function, and this downregulation is linked to increased PVL. | |||||
抄録(URL) | ||||||
Characterization of microRNA expression in B cells derived from Japanese black cattle naturally infected with bovine leukemia virus by deep sequencing | ||||||
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0256588 | ||||||
出版者 | ||||||
出版者 | Public Library of Science | |||||
権利 | ||||||
権利情報 | © 2021 Ochiai et al. | |||||
権利URI | ||||||
権利情報 | https://creativecommons.org/licenses/by/4.0/ | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1371/journal.pone.0256588 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |