DKK-Toa Yamagata Co.
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
Institute of Livestock and Grassland Science, NARO
Awaji Agricultural Technology Center
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Department of Animal Resources Science, Dankook University
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
登録日
2022-01-19
雑誌名
Journal of Veterinary Medical Science
巻
83
号
6
ページ
905 - 910
発行年
2021
ISSN
13477439
09167250
抄録
The effects of anti-lipopolysaccharide (LPS) antibody on rumen fermentation and LPS activity were investigated during subacute ruminal acidosis (SARA) challenge. Eleven Holstein cattle (164 ± 14 kg) were used in a 3 × 3 Latin square design. Cattle were fed a roughage diet on days −11 to −1 (pre-challenge) and day 2 (post-challenge), and a high-grain diet on days 0 and 1 (SARA challenge). For 14 days, 0-, 2-, or 4-g of anti-LPS antibody was administered once daily through a rumen fistula. Ruminal pH was measured continuously, and rumen fluid and blood samples were collected on days −1, 0, 1, and 2. Significantly lower ruminal LPS activity on day 1 was observed in the 2- and 4-g groups than those in the 0-g group. In addition, significantly higher 1-hr mean ruminal pH on SARA challenge period (days 0 and 1) was identified in the 4-g group than in the 0-g group. However, rumen fermentation measurements (total volatile fatty acid [VFA], VFA components, NH3-N and lactic acid) and peripheral blood metabolites (glucose, free fatty acid, beta-hydroxybutyrate, total cholesterol, blood urea nitrogen, aspartate aminotransferase and gamma-glutamyl transferase) were not different among the groups during the experimental periods. Therefore, anti-LPS antibody administration mitigates LPS release and pH depression without the depression of rumen fermentation and peripheral blood metabolites during SARA challenge in Holstein cattle.
Anti-lipopolysaccharide antibody administration mitigates ruminal lipopolysaccharide release and depression of ruminal pH during subacute ruminal acidosis challenge in Holstein bull cattle
jvms-v83n6p905-910
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