{"created":"2023-05-15T12:05:39.040641+00:00","id":10338,"links":{},"metadata":{"_buckets":{"deposit":"10793f41-e6a9-43f6-b787-2686b7036b3b"},"_deposit":{"created_by":3,"id":"10338","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"10338"},"status":"published"},"_oai":{"id":"oai:iwate-u.repo.nii.ac.jp:00010338","sets":["1515:1519"]},"author_link":["64090","64089"],"item_16_alternative_title_23":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Application of layered double hydroxides as material for drug delivery"}]},"item_16_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"81","bibliographicPageStart":"75","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"粘土科学"}]}]},"item_16_date_6":{"attribute_name":"登録日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-09-08"}]},"item_16_description_12":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Layered double hydroxide (LDH) is widely known as anionic clay, host-guest material and anion-exchanger. LDH is a class of nanomaterials that have attracted considerable attention for their potential utility as material for drug and biomolecule delivery. In this study, the intercalation behavior of anticancer drug (5-fluorouracil: 5-FU), the synthesis of 5-FU/Mg-Al LDH and peptide modified 5-FU/LDH (peptide/5-FU/LDH) have been investigated. Moreover, the cytotoxicity assay of the both LDHs for mammalian cells has also been studied. The 5-FU/LDH was characterized by various techniques such as XRD and FT-IR that demonstrated the intercalation of 5-FU into the LDH by using coprecipitation and ion exchange methods.\nThen, the surface of the 5-FU/LDH was modified with collagen and soy bean peptides. After the modification, the peptide/5-FU/LDH maintained its original LDH structure. The results of cytotoxicity assay for mammalian cells showed that the 5-FU/LDH and the peptide/5-FU/LDH have 1.9 and 7.7 times better drug efficacy than naked 5-FU. The peptide/5-FU/LDH exhibited a quick cytotoxic effect compared with the 5-FU/LDH. The present results suggest that LDH and the peptide modified LDH have the great potential of the materials for drug delivery.","subitem_description_type":"Other"}]},"item_16_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"64090","nameIdentifierScheme":"WEKO"}],"names":[{"name":"AISAWA, Sumio"}]}]},"item_16_publisher_14":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本粘土学会"}]},"item_16_text_4":{"attribute_name":"著者(機関)","attribute_value_mlt":[{"subitem_text_value":"岩手大学大学院工学研究科"}]},"item_16_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"會澤, 純雄"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-11-14"}],"displaytype":"detail","filename":"nk-v48n3p137-144.pdf","filesize":[{"value":"3.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"nk-v48n3p137-144.pdf","url":"https://iwate-u.repo.nii.ac.jp/record/10338/files/nk-v48n3p137-144.pdf"},"version_id":"127101be-8522-404a-9361-6f863ef83770"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Layered double hydroxide","subitem_subject_scheme":"Other"},{"subitem_subject":"Intercalation","subitem_subject_scheme":"Other"},{"subitem_subject":"Anticancer drug","subitem_subject_scheme":"Other"},{"subitem_subject":"Peptide","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytotoxicity","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"層状複水酸化物のドラッグデリバリー材料としての応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"層状複水酸化物のドラッグデリバリー材料としての応用"}]},"item_type_id":"16","owner":"3","path":["1519"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-09-08"},"publish_date":"2014-09-08","publish_status":"0","recid":"10338","relation_version_is_last":true,"title":["層状複水酸化物のドラッグデリバリー材料としての応用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T11:36:56.939133+00:00"}