{"created":"2023-05-15T12:09:52.713040+00:00","id":15466,"links":{},"metadata":{"_buckets":{"deposit":"9977264f-e2d5-4ee6-8ba0-fcdd11637455"},"_deposit":{"created_by":19,"id":"15466","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"15466"},"status":"published"},"_oai":{"id":"oai:iwate-u.repo.nii.ac.jp:00015466","sets":["1515:1519"]},"author_link":["93379","93381","93384","93386","93383","93385","93378","93382","93380"],"item_16_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-07","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"126","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Scientific Data"}]}]},"item_16_date_6":{"attribute_name":"登録日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-12-08"}]},"item_16_description_11":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cellular immortalization enables indefinite expansion of cultured cells. However, the process of cell immortalization sometimes changes the original nature of primary cells. In this study, we performed expression profiling of poly A-tailed RNA from primary and immortalized corneal epithelial cells expressing Simian virus 40 large T antigen (SV40) or the combination of mutant cyclin-dependent kinase 4 (CDK4), cyclin D1, and telomere reverse transcriptase (TERT). Furthermore, we studied the expression profile of SV40 cells cultured in medium with or without serum. The profiling of whole expression pattern revealed that immortalized corneal epithelial cells with SV40 showed a distinct expression pattern from wild-type cells regardless of the presence or absence of serum, while corneal epithelial cells with combinatorial expression showed an expression pattern relatively closer to that of wild-type cells.","subitem_description_type":"Abstract"}]},"item_16_publisher_14":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_16_relation_17":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"The transcriptome of wild-type and immortalized corneal epithelial cells"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41597-021-00908-9","subitem_relation_type_select":"URI"}}]},"item_16_relation_26":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/s41597-021-00908-9","subitem_relation_type_select":"DOI"}}]},"item_16_rights_18":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2021"}]},"item_16_rights_19":{"attribute_name":"権利URI","attribute_value_mlt":[{"subitem_rights":"http://creativecommons.org/licenses/by/4.0/"}]},"item_16_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"20524463","subitem_source_identifier_type":"ISSN"}]},"item_16_text_4":{"attribute_name":"著者(機関)","attribute_value_mlt":[{"subitem_text_value":"Graduate School of Science and Engineering, Iwate University"},{"subitem_text_value":"Graduate School of Science and Engineering, Iwate University"},{"subitem_text_value":"Graduate School of Science and Engineering, Iwate University"},{"subitem_text_value":"Graduate School of Science and Engineering, Iwate University"},{"subitem_text_value":"Graduate School of Science and Engineering, Iwate University"},{"subitem_text_value":"Exploratory Oncology Research and Clinical Trial Center, National Cancer Center"},{"subitem_text_value":"Rohto Pharmaceutical Co., Ltd., Basic Research Development Division"},{"subitem_text_value":"Rohto Pharmaceutical Co., Ltd., Basic Research Development Division"},{"subitem_text_value":"Graduate School of Science and Engineering, Iwate University"}]},"item_16_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"FURUYA, Kai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WU, Tao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ORIMOTO, Ai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUGANO, Eriko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TOMITA, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KIYONO, Tohru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KUROSE, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKAI, Yoshihiro "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FUKUDA, Tomokazu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-12-08"}],"displaytype":"detail","filename":"sd-v8p126.pdf","filesize":[{"value":"5.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"sd-v8p126","url":"https://iwate-u.repo.nii.ac.jp/record/15466/files/sd-v8p126.pdf"},"version_id":"dbee2349-adf1-41fd-871e-5f2928affaa0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The transcriptome of wild-type and immortalized corneal epithelial cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The transcriptome of wild-type and immortalized corneal epithelial cells"}]},"item_type_id":"16","owner":"19","path":["1519"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-12-08"},"publish_date":"2021-12-08","publish_status":"0","recid":"15466","relation_version_is_last":true,"title":["The transcriptome of wild-type and immortalized corneal epithelial cells"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-05-15T13:04:14.269974+00:00"}