{"created":"2023-05-15T12:09:53.557220+00:00","id":15488,"links":{},"metadata":{"_buckets":{"deposit":"8a1557c3-ea14-4b8f-a4d2-ab2289a985e9"},"_deposit":{"created_by":19,"id":"15488","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"15488"},"status":"published"},"_oai":{"id":"oai:iwate-u.repo.nii.ac.jp:00015488","sets":["1515:1519"]},"author_link":["93540","93541","93542","93544","93543","93539","93545","93547","93546"],"item_16_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-11-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"16533","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_16_date_6":{"attribute_name":"登録日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-12-16"}]},"item_16_description_11":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Non-invasive remote control technologies designed to manipulate neural functions have been long-awaited for the comprehensive and quantitative understanding of neuronal network in the brain as well as for the therapy of neurological disorders. Recently, it has become possible for the neuronal activity to be optically manipulated using biological photo-reactive molecules such as channelrhodopsin (ChR)-2. However, ChR2 and its relatives are mostly reactive to visible light, which does not effectively penetrate through biological tissues. In contrast, near-infrared (NIR) light (650–1450 nm) penetrates deep into the tissues because biological systems are almost transparent to light within this so-called ‘imaging window’. Here we used lanthanide nanoparticles (LNPs), composed of rare-earth elements, as luminous bodies to activate ChRs since they absorb low-energy NIR light to emit high-energy visible light (up-conversion). Here, we created a new type of optogenetic system which consists of the donor LNPs and the acceptor ChRs. The NIR laser irradiation emitted visible light from LNPs, then induced the photo-reactive responses in the near-by cells that expressed ChRs. However, there remains room for large improvements in the energy efficiency of the LNP-ChR system.","subitem_description_type":"Abstract"}]},"item_16_publisher_14":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_16_relation_17":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Near-infrared (NIR) up-conversion optogenetics"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/srep16533","subitem_relation_type_select":"URI"}}]},"item_16_relation_26":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/srep16533","subitem_relation_type_select":"DOI"}}]},"item_16_rights_19":{"attribute_name":"権利URI","attribute_value_mlt":[{"subitem_rights":"http://creativecommons.org/licenses/by/4.0/"}]},"item_16_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_16_text_4":{"attribute_name":"著者(機関)","attribute_value_mlt":[{"subitem_text_value":"Department of Developmental Biology and Neuroscience, Tohoku University Graduate School of Life Sciences"},{"subitem_text_value":"Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology"},{"subitem_text_value":"Department of Developmental Biology and Neuroscience, Tohoku University Graduate School of Life Sciences"},{"subitem_text_value":"Department of Developmental Biology and Neuroscience, Tohoku University Graduate School of Life Sciences"},{"subitem_text_value":"Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University"},{"subitem_text_value":"Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University"},{"subitem_text_value":"Laboratory of Visual Neuroscience, Department of Chemistry and Bioengineering, Iwate University Graduate School of Engineering"},{"subitem_text_value":"Laboratory of Visual Neuroscience, Department of Chemistry and Bioengineering, Iwate University Graduate School of Engineering, Clinical Research, Innovation and Education Center, Tohoku University Hospital"},{"subitem_text_value":"Department of Developmental Biology and Neuroscience, Tohoku University Graduate School of Life Sciences, Center for Neuroscience, Tohoku University Graduate School of Medicine"}]},"item_16_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HOSOSHIMA, Shoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YUASA, Hideya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ISHIZUKA, Toru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mohammad Razuanul Hoque"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMASHITA, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMANAKA, Akihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUGANO, Eriko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TOMITA, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAWO, Hiromu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-12-16"}],"displaytype":"detail","filename":"sr-v5p16553.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"sr-v5p16553","url":"https://iwate-u.repo.nii.ac.jp/record/15488/files/sr-v5p16553.pdf"},"version_id":"24ac47fc-d923-4bef-92ed-8ec0b9413573"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Near-infrared (NIR) up-conversion optogenetics","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Near-infrared (NIR) up-conversion optogenetics"}]},"item_type_id":"16","owner":"19","path":["1519"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-12-16"},"publish_date":"2021-12-16","publish_status":"0","recid":"15488","relation_version_is_last":true,"title":["Near-infrared (NIR) up-conversion optogenetics"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-05-15T13:03:27.496947+00:00"}