{"created":"2023-05-15T12:09:55.266681+00:00","id":15529,"links":{},"metadata":{"_buckets":{"deposit":"d1bad34a-5c7f-4487-b503-c1976b26c4cf"},"_deposit":{"created_by":19,"id":"15529","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"15529"},"status":"published"},"_oai":{"id":"oai:iwate-u.repo.nii.ac.jp:00015529","sets":["1504:1510"]},"author_link":["93825","93823","93822","93824","93826","93821"],"item_16_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"24","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"Lipids in Health and Disease"}]}]},"item_16_date_6":{"attribute_name":"登録日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-01-24"}]},"item_16_description_11":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nDietary sphingolipids have various biofunctions, including skin barrier improvement and anti-inflammatory and anti-carcinoma properties. Long-chain bases (LCBs), the essential backbones of sphingolipids, are expected to be important for these bioactivities, and they vary structurally between species. Given these findings, however, the absorption dynamics of each LCB remain unclear.\n\nMethods\nIn this study, five structurally different LCBs were prepared from glucosylceramides (GlcCers) with LCB 18:2(4E,8Z);2OH and LCB 18:2(4E,8E);2OH moieties derived from konjac tuber (Amorphophallus konjac), from GlcCers with an LCB 18(9Me):2(4E,8E);2OH moiety derived from Tamogi mushroom (Pleurotus cornucopiae var. citrinopileatus), and from ceramide 2-aminoethyphosphonate with LCB 18:3(4E,8E,10E);2OH moiety and LCB 18(9Me):3(4E,8E,10E);2OH moiety derived from giant scallop (Mizuhopecten yessoensis), and their absorption percentages and metabolite levels were analyzed using a lymph-duct-cannulated rat model via liquid chromatography tandem mass spectrometry (LC/MS/MS) with a multistage fragmentation method.\n\nResults\nThe five orally administered LCBs were absorbed and detected in chyle (lipid-containing lymph) as LCBs and several metabolites including ceramides, hexosylceramides, and sphingomyelins. The absorption percentages of LCBs were 0.10–1.17%, depending on their structure. The absorption percentage of LCB 18:2(4E,8Z);2OH was the highest (1.17%), whereas that of LCB 18:3(4E,8E,10E);2OH was the lowest (0.10%). The amount of sphingomyelin with an LCB 18:2(4E,8Z);2OH moiety in chyle was particularly higher than sphingomyelins with other LCB moieties.\n\nConclusions\nStructural differences among LCBs, particularly geometric isomerism at the C8–C9 position, significantly affected the absorption percentages and ratio of metabolites. This is the first report to elucidate that the absorption and metabolism of sphingolipids are dependent on their LCB structure. These results could be used to develop functional foods that are more readily absorbed.","subitem_description_type":"Abstract"}]},"item_16_publisher_14":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central"}]},"item_16_relation_17":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://lipidworld.biomedcentral.com/articles/10.1186/s12944-021-01448-2","subitem_relation_type_select":"URI"}}]},"item_16_relation_26":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1186/s12944-021-01448-2","subitem_relation_type_select":"DOI"}}]},"item_16_rights_18":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s). 2021"}]},"item_16_rights_19":{"attribute_name":"権利URI","attribute_value_mlt":[{"subitem_rights":"http://creativecommons.org/licenses/by/4.0/"}]},"item_16_source_id_25":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA1203677X","subitem_source_identifier_type":"NCID"}]},"item_16_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1476511X","subitem_source_identifier_type":"ISSN"}]},"item_16_text_4":{"attribute_name":"著者(機関)","attribute_value_mlt":[{"subitem_text_value":"Laboratory of Biomembrane and Biofunctional Chemistry, Graduate School of Advanced Life Science, and Frontier Research Center for Post-Genome Science and Technology, Hokkaido University"},{"subitem_text_value":"Department of Biochemistry & Cell Biology, National Institute of Infectious Diseases"},{"subitem_text_value":"Department of Animal Science, Faculty of Agriculture, Iwate University"},{"subitem_text_value":"Laboratory of Biomembrane and Biofunctional Chemistry, Graduate School of Advanced Life Science, and Frontier Research Center for Post-Genome Science and Technology, Hokkaido University"},{"subitem_text_value":"Laboratory of Biomembrane and Biofunctional Chemistry, Graduate School of Advanced Life Science, and Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, R & D Headquarters, Daicel Corporation"},{"subitem_text_value":"Laboratory of Biomembrane and Biofunctional Chemistry, Graduate School of Advanced Life Science, and Frontier Research Center for Post-Genome Science and Technology, Hokkaido University"}]},"item_16_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MIKAMI, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAKAI, Shota"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NISHIMUKAI, Megumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YUYAMA, Kohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MUKAI, Katsuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IGARASHI, Yasuyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-24"}],"displaytype":"detail","filename":"lhd-v20p24.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"lhd-v20p24","url":"https://iwate-u.repo.nii.ac.jp/record/15529/files/lhd-v20p24.pdf"},"version_id":"311b8999-ab25-4643-8d82-3d4bbe4dcbdb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Sphingolipids","subitem_subject_scheme":"Other"},{"subitem_subject":"Long-chain base","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipid metabolism","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipidomics","subitem_subject_scheme":"Other"},{"subitem_subject":"Lymphatic absorption","subitem_subject_scheme":"Other"},{"subitem_subject":"Sphingomyelin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph"}]},"item_type_id":"16","owner":"19","path":["1510"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-01-24"},"publish_date":"2022-01-24","publish_status":"0","recid":"15529","relation_version_is_last":true,"title":["Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-05-15T13:01:51.087193+00:00"}