{"created":"2023-05-15T12:10:07.587369+00:00","id":15772,"links":{},"metadata":{"_buckets":{"deposit":"191f5a43-879e-4735-a3e1-f5c7b51671b0"},"_deposit":{"created_by":19,"id":"15772","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"15772"},"status":"published"},"_oai":{"id":"oai:iwate-u.repo.nii.ac.jp:00015772","sets":["1504:1510"]},"author_link":["95001","94998","95000","95002","94996","94997","94989","94994","94992","94990","94988","94995","94999","94993","94991"],"item_16_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageStart":"e0256588","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"PLoS ONE"}]}]},"item_16_date_6":{"attribute_name":"登録日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-08-26"}]},"item_16_description_11":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis (EBL), a malignant B cell lymphoma. However, the mechanisms of BLV-associated lymphomagenesis remain poorly understood. Here, after deep sequencing, we performed comparative analyses of B cell microRNAs (miRNAs) in cattle infected with BLV and those without BLV. In BLV-infected cattle, BLV-derived miRNAs (blv-miRNAs) accounted for 38% of all miRNAs in B cells. Four of these blv-miRNAs (blv-miR-B1-5p, blv-miR-B2-5p, blv-miR-B4-3p, and blv-miR-B5-5p) had highly significant positive correlations with BLV proviral load (PVL). The read counts of 90 host-derived miRNAs (bta-miRNAs) were significantly down-regulated in BLV-infected cattle compared to those in uninfected cattle. Only bta-miR-375 had a positive correlation with PVL in BLV-infected cattle and was highly expressed in the B cell lymphoma tissue of EBL cattle. There were a few bta-miRNAs that correlated with BLV tax/rex gene expression; however, BLV AS1 expression had a significant negative correlation with many of the down-regulated bta-miRNAs that are important for tumor development and/or tumor suppression. These results suggest that BLV promotes lymphomagenesis via AS1 and blv-miRNAs, rather than tax/rex, by down-regulating the expression of bta-miRNAs that have a tumor-suppressing function, and this downregulation is linked to increased PVL.","subitem_description_type":"Abstract"}]},"item_16_link_13":{"attribute_name":"抄録（URL）","attribute_value_mlt":[{"subitem_link_text":"Characterization of microRNA expression in B cells derived from Japanese black cattle naturally infected with bovine leukemia virus by deep sequencing","subitem_link_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0256588"}]},"item_16_publisher_14":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_16_relation_26":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1371/journal.pone.0256588","subitem_relation_type_select":"DOI"}}]},"item_16_rights_18":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":" © 2021 Ochiai et al."}]},"item_16_rights_19":{"attribute_name":"権利URI","attribute_value_mlt":[{"subitem_rights":"https://creativecommons.org/licenses/by/4.0/"}]},"item_16_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"19326203","subitem_source_identifier_type":"ISSN"}]},"item_16_text_4":{"attribute_name":"著者(機関)","attribute_value_mlt":[{"subitem_text_value":"Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University , Food Safety and Consumer Affairs Bureau, Ministry of Agriculture, Forestry and Fisheries"},{"subitem_text_value":"Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University , Department of Agriculture, Forestry and Fisheries, Ehime Prefectural Government"},{"subitem_text_value":"Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University , Department of Agriculture, Forestry and Fisheries, Iwate Prefectural Government"},{"subitem_text_value":"Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University"},{"subitem_text_value":"Graduate School of Veterinary Sciences, Iwate University"},{"subitem_text_value":"Graduate School of Veterinary Sciences, Iwate University"},{"subitem_text_value":"Graduate School of Veterinary Sciences, Iwate University"},{"subitem_text_value":"Graduate School of Veterinary Sciences, Iwate University"},{"subitem_text_value":"Field Science Center, Faculty of Agriculture, Iwate University"},{"subitem_text_value":"Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University"},{"subitem_text_value":"Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University"},{"subitem_text_value":"Division of Bacterial and Parasitic Disease, National Institute of Animal Health"},{"subitem_text_value":"Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University , Graduate School of Veterinary Sciences, Iwate University"},{"subitem_text_value":"Department of Animal Sciences, Teikyo University of Science"},{"subitem_text_value":"Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University , Graduate School of Veterinary Sciences, Iwate University"}]},"item_16_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OCHIAI, Chihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MIYAUCHI, Sonoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KUDO, Yuta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NARUKE, Yuta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YONEYAMA, Syuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TOMITA, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"DONGZE, Leng"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"CHIBA, Yusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HIRATA, To-Ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ICHIJO, Toshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAGAI, Kazuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOBAYASHI, Sota"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMADA, Shinji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HIKONO, Hirokazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MURAKMI, Kenji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-08-26"}],"displaytype":"detail","filename":"ploso-v19n9pe0256588.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ploso-v19n9pe0256588","url":"https://iwate-u.repo.nii.ac.jp/record/15772/files/ploso-v19n9pe0256588.pdf"},"version_id":"b017ded3-919d-42e0-a787-c986a3908ee2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Characterization of microRNA expression in B cells derived from Japanese black cattle naturally infected with bovine leukemia virus by deep sequencing","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Characterization of microRNA expression in B cells derived from Japanese black cattle naturally infected with bovine leukemia virus by deep sequencing"}]},"item_type_id":"16","owner":"19","path":["1510"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-08-26"},"publish_date":"2022-08-26","publish_status":"0","recid":"15772","relation_version_is_last":true,"title":["Characterization of microRNA expression in B cells derived from Japanese black cattle naturally infected with bovine leukemia virus by deep sequencing"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-05-15T12:51:40.573435+00:00"}