{"created":"2025-08-25T05:16:29.086030+00:00","id":2000855,"links":{},"metadata":{"_buckets":{"deposit":"bf48733c-3e55-44e8-86ab-14a3fa06f3aa"},"_deposit":{"created_by":19,"id":"2000855","owner":"19","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"2000855"},"status":"published"},"_oai":{"id":"oai:iwate-u.repo.nii.ac.jp:02000855","sets":["1515:1519"]},"author_link":[],"control_number":"2000855","item_16_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-12-27","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicNumberOfPages":"15","bibliographicPageEnd":"39","bibliographicPageStart":"25","bibliographicVolumeNumber":"50","bibliographic_titles":[{"bibliographic_title":"Cell Structure and Function","bibliographic_titleLang":"en"}]}]},"item_16_date_6":{"attribute_name":"登録日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2025-08-26","subitem_date_issued_type":"Created"}]},"item_16_description_11":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Membrane stiffness is essential for cell migration, tumorigenesis, and development; however, the physical properties of intracellular membrane are poorly characterized. In this study, we internalized 20 nm magnetic nanoparticles (MNPs) into MCF7 human breast cancer cells and applied a magnetic field. We investigated whether magnetic field could induce membrane damage of the early endosomes by analyzing the colocalization of MNPs with galectin 3 (Gal3), a cytosolic protein recruited to the lumen of damaged organelles. We first tried to apply magnetic field by electromagnet, and found a direct-current (DC) magnetic field for five minutes increased the colocalization of the MNPs with Gal3, suggesting that the magnetic field damaged the endosomal membrane. We used a neodymium magnet to apply longer and stronger static magnetic fields. The static magnetic field more than 50 mT for five minutes started to damage endosomes, while 100 mT was the most effective. Longer exposure or higher magnetic field strengths did not induce further membrane damage. We confirmed that a Gal3 positive compartment was also positive for the early endosome marker, EEA1, suggesting that the external magnetic field induced membrane damage in the early endosomes. Our results indicate that a static magnetic field can control the membrane damage in early endosomes using internalized MNPs.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_16_description_56":{"attribute_name":"内容注記","attribute_value_mlt":[{"subitem_description":"This article is reproduced under the CC BY 4.0 license from \"Magnetic control of membrane damage in early endosomes using internalized magnetic nanoparticles\" (https://doi.org/10.1247/csf.24037) by The Author(s).","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_16_publisher_14":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japan Society for Cell Biology","subitem_publisher_language":"en"}]},"item_16_relation_26":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1247/csf.24037","subitem_relation_type_select":"DOI"}}]},"item_16_rights_18":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Creative Commons Attribution 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by/4.0/"},{"subitem_rights":"© 2025 The Author(s)","subitem_rights_language":"en"}]},"item_16_source_id_25":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA0060007X","subitem_source_identifier_type":"NCID"}]},"item_16_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-3700","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"0386-7196","subitem_source_identifier_type":"PISSN"}]},"item_16_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Iwate 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University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"SAITO, Nana","creatorNameLang":"en","creatorNameType":"Personal"}],"creatorType":"著"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Iwate University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"OIKAWA, Ibuki","creatorNameLang":"en","creatorNameType":"Personal"}],"creatorType":"著"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Iwate University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"YAMADA, Ryohei","creatorNameLang":"en","creatorNameType":"Personal"}],"creatorType":"著"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"National Chiayi University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"CHEN, Yu-han","creatorNameLang":"en","creatorNameType":"Personal"}],"creatorType":"著"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Iwate University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"OYANAGI, Koichi","creatorNameLang":"en","creatorNameType":"Personal"}],"creatorType":"著"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Iwate Univeresity","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"SHIBASAKI, Yuji","creatorNameLang":"en","creatorNameType":"Personal"}],"creatorType":"著"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Iwate University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"KOBAYASHI, Satoru","creatorNameLang":"en","creatorNameType":"Personal"}],"creatorType":"著"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Iwate University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"SHIBA, Yoko","creatorNameLang":"en","creatorNameType":"Personal"}],"creatorType":"著"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-08-25"}],"filename":"csf-v50i1p25-39.pdf","filesize":[{"value":"14.7 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"csf-v50i1p25-39.pdf","objectType":"fulltext","url":"https://iwate-u.repo.nii.ac.jp/record/2000855/files/csf-v50i1p25-39.pdf"},"version_id":"1b704993-137a-416f-9355-880520eae4c0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"magnetic nanoparticles","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endosomes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"membrane damage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"organelle","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Magnetic control of membrane damage in early endosomes using internalized magnetic nanoparticles","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Magnetic control of membrane damage in early endosomes using internalized magnetic nanoparticles","subitem_title_language":"en"}]},"item_type_id":"16","owner":"19","path":["1519"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-08-26"},"publish_date":"2025-08-26","publish_status":"0","recid":"2000855","relation_version_is_last":true,"title":["Magnetic control of membrane damage in early endosomes using internalized magnetic nanoparticles"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2025-08-26T06:06:13.245135+00:00"}