| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-12-03 |
| タイトル |
|
|
タイトル |
Reduction of urinary felinine in domestic cats with renal diseases leads to decreased catty odor |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
domestic cat |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
felinine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mass spectrometry |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
renal diseases |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
urinary odor |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
SUKA, Ayaka
UENOYAMA, Reiko
ICHIZAWA, Shota
KATAYAMA, Masaaki
MIYAZAKI, Masao
MIYAZAKI, Tamako
|
| 登録日 |
|
|
日付 |
2025-12-03 |
|
日付タイプ |
Created |
| 書誌情報 |
en : The Journal of Veterinary Medical Science
巻 87,
号 1,
p. 61-67,
ページ数 7,
発行日 2024-12-03
|
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1347-7439 |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0916-7250 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Cats with progressive renal diseases often exhibit a weakened urinary odor, in contrast to normal cat urine which emits odorants with catty odor, such as 3-mercapto-3-methyl-1-butanol, 3-mercapto-3-methylbutyl formate, 3-methyl-3-methylthio-1-butanol, and 3-methyl-3-(2-methyldisulfanyl)-1-butanol. Felinine, an amino acid, is a precursor of these odorants and metabolized from its precursor, 3-methylbutanol glutathione (MBG), via 3-methylbutanol-cysteinylglycine (MBCG). While previous studies have reported felinine excretion in normal cats, its levels in cats with renal diseases remain unclear. This study investigates the urinary excretion of felinine and its precursors in cats with renal diseases and explores whether changes in these metabolites are linked to reduced volatile felinine derivatives with catty odor. Liquid chromatography/mass spectrometry quantified urinary felinine, MBCG, and MBG in 40 normal cats and 66 cats with renal diseases (classified into mild, moderate, and severe renal diseases), revealing a significant decrease in urinary felinine levels in cats with advanced renal disease, while urinary MBG levels increased. The felinine-to-MBG ratio was significantly lower in cats with severe renal disease compared to normal cats and those with mild renal disease. Gas chromatography/mass spectrometry analysis further showed that the emission of felinine derivatives decreased markedly with renal disease progression. A significant correlation was found between urinary felinine excretion and its major derivative, 3-methyl-3-methylthio-1-butanol. These findings suggest that impaired felinine metabolism, likely due to reduced kidney enzyme activity, contributes to both diminished urinary felinine levels and reduced sulfurous odor in cats with renal diseases. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
The Japanese Society of Veterinary Science |
|
言語 |
en |
| 権利 |
|
|
言語 |
en |
|
権利情報Resource |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1292/jvms.24-0370 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 助成情報 |
|
|
|
助成機関名 |
Japan Society for the Promotion of Science |
|
|
言語 |
en |
|
|
研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19321/ |
|
|
研究課題番号 |
22K19321 |
|
|
研究課題番号タイプ |
JGN |
|
|
研究課題名 |
現代人はネコの脂質代謝を模倣して高コレステロール血症を克服できるか？ |
|
|
言語 |
ja |
| 内容注記 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was funded by JSPS under KAKENHI Grant numbers 22K19321 (M.M.). |
|
言語 |
en |
jvms-v87i1p61-67.pdf (1.2 MB)
