{"created":"2023-05-15T12:04:31.165507+00:00","id":9073,"links":{},"metadata":{"_buckets":{"deposit":"6132c59f-4448-43de-b6d3-f6727ebf7eea"},"_deposit":{"created_by":3,"id":"9073","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"9073"},"status":"published"},"_oai":{"id":"oai:iwate-u.repo.nii.ac.jp:00009073","sets":["1504:1510"]},"author_link":["71557","71556","71559","71558"],"item_16_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"110","bibliographicPageStart":"101","bibliographicVolumeNumber":"163","bibliographic_titles":[{"bibliographic_title":"The Tohoku Journal of Experimental Medicine"}]}]},"item_16_date_6":{"attribute_name":"登録日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-01-22"}]},"item_16_description_12":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"ODA, S., FUJIMURA, H., SASAKI, Y, and OHNEDA, A. α2-Adrenergic Modulation of Glucagon and Insulin Secretions in Sheep. Tohoku J. Exp. Med., 1991, 163 (2), 101-110 - To investigate the effects of α2-adrenergic receptors on the secretions of pancreatic glucagon and insulin, clonidine, midaglizole and yohimbine were intravenously administered in four conscious sheep. Clonidine infusion at a dosage of 1.0nmol/kg/min produced hyperglucagonemia, hypoinsulinemia and hyperglycemia. Midaglizole or yohimbine was infused for 30min, at doses of 5, 10 and 50nmol/kg/min during the clonidine infusion. The highest yohimbine infusion (50nmol/kg/min) blocked the clonidine-induced responses of glucagon, insulin and glucose. On the other hand, the midaglizole (50nmol/kg/min) infusion brought about no statistical effect on the clonidine-induced responses of glucagon, insulin and glucose. The α2-adrenergic antagonistic effect of midaglizole was clearly less than that of yohimbine in the present experiments. It is concluded that the glucagon secretion is enhanced and the insulin release is inhibited by α2-adrenergic stimulation in conscious sheep.","subitem_description_type":"Other"}]},"item_16_publisher_14":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東北ジャーナル刊行会"}]},"item_16_relation_26":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1620/tjem.163.101","subitem_relation_type_select":"DOI"}}]},"item_16_rights_18":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 東北ジャーナル刊行会"},{"subitem_rights":"©J-STAGE"}]},"item_16_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-8727","subitem_source_identifier_type":"ISSN"}]},"item_16_text_4":{"attribute_name":"著者(機関)","attribute_value_mlt":[{"subitem_text_value":"Laboratory of Animal Physiology, Faculty of Agriculture,Tohoku University"},{"subitem_text_value":"Laboratory of Animal Physiology, Faculty of Agriculture, Tohoku University"},{"subitem_text_value":"Laboratory of Animal Physiology, Faculty of Agriculture,Tohoku University"},{"subitem_text_value":"Health Center, Tohoku University"}]},"item_16_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ODA, SHINICHI"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FUJIMURA, HIDEAKI"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SASAKI, YASUYUKI"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OHNEDA, AKIRA"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-11-14"}],"displaytype":"detail","filename":"tjem-v163n2p101-110.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"tjem-v163n2p101-110.pdf","url":"https://iwate-u.repo.nii.ac.jp/record/9073/files/tjem-v163n2p101-110.pdf"},"version_id":"f825c840-2893-482c-b2dd-0912ddbfaa47"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"clonidine","subitem_subject_scheme":"Other"},{"subitem_subject":"midaglizole","subitem_subject_scheme":"Other"},{"subitem_subject":"yohimbine","subitem_subject_scheme":"Other"},{"subitem_subject":"glucagon","subitem_subject_scheme":"Other"},{"subitem_subject":"insulin","subitem_subject_scheme":"Other"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"α2-Adrenergic Modulation of Glucagon and Insulin Secretions in Sheep","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"α2-Adrenergic Modulation of Glucagon and Insulin Secretions in Sheep"}]},"item_type_id":"16","owner":"3","path":["1510"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-01-22"},"publish_date":"2009-01-22","publish_status":"0","recid":"9073","relation_version_is_last":true,"title":["α2-Adrenergic Modulation of Glucagon and Insulin Secretions in Sheep"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T11:16:35.552713+00:00"}