{"created":"2023-05-15T12:04:31.478582+00:00","id":9080,"links":{},"metadata":{"_buckets":{"deposit":"5c26167a-1e6b-4fa1-8fc3-e81b6eebca9b"},"_deposit":{"created_by":3,"id":"9080","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"9080"},"status":"published"},"_oai":{"id":"oai:iwate-u.repo.nii.ac.jp:00009080","sets":["1504:1510"]},"author_link":["71602","71604","71599","71600","71601","71603"],"item_16_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"141","bibliographicPageStart":"133","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"岩手県獣医師会会報"}]}]},"item_16_date_6":{"attribute_name":"登録日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-02-23"}]},"item_16_description_12":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"リンパ増殖性腫瘍疾患およびレトロウイルス疾患の病態進行に腫瘍壊死因子（TNF-α）が重要な役割を演ずることが報告されている．そこで我々は29例の地方病性牛白血病（EBL)牛を用いて，腫瘍細胞での腫瘍壊死因子受容体（TNF-RⅠ，RⅡ）の発現パターンを免疫組織化学的に検索した．腫瘍組織は病理組織学的にDiffuse mixed type（10例），Diffuse large type（9例），Diffuse large cleaved type(10例）の3タイプのリンパ腫に分類され，牛リンパ球表面抗原に対するモノクローナル抗体を用いた腫瘍細胞のフェノタイピングでは，B-1a（CD５+/CD11b+），B-1b(CD５-/CD11b+），B-2（conventional B）（CD5-/CD11b-）の3タイプに分類された．興味深いことに，全ての症例の腫瘍細胞においてTNF-RⅡの発現タイプは認められたが，TNF-RⅠの発現は認められなかった．EBLでは組織学的，免疫フェノタイプで症例ごとに異なるリンパ腫が形成されていたが，TNF-Rの発現パターンは全てのリンパ腫細胞において統一性を有していた．細胞増殖反応を誘発するTNF-RⅡが全ての腫瘍細胞に発現し，アポトーシスを誘発するTNF-RⅠが発現していなかったという結果は，TNF-RがEBLにおいてB細胞の腫瘍性増殖とリンパ腫の形成に重要な役割を演ずることを示していた．","subitem_description_type":"Other"}]},"item_16_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"71602","nameIdentifierScheme":"WEKO"}],"names":[{"name":"IKEDA, Manabu"}]},{"nameIdentifiers":[{"nameIdentifier":"71603","nameIdentifierScheme":"WEKO"}],"names":[{"name":"GORYO, Masanobu"}]},{"nameIdentifiers":[{"nameIdentifier":"71604","nameIdentifierScheme":"WEKO"}],"names":[{"name":"OKADA, Kosuke"}]}]},"item_16_publisher_14":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"社団法人　岩手県獣医師会"}]},"item_16_rights_18":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"©　社団法人岩手県獣医師会"}]},"item_16_text_4":{"attribute_name":"著者(機関)","attribute_value_mlt":[{"subitem_text_value":"岐阜大学大学院連合獣医学研究科病態獣医学連合講座, 独立行政法人放射線医学総合研究所"},{"subitem_text_value":"岩手支会　岩手大学農学部獣医学科獣医病理学研究室"}]},"item_16_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池田, 学"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"御領, 政信"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岡田, 幸助"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-11-14"}],"displaytype":"detail","filename":"iv-v31n4p133-141.pdf","filesize":[{"value":"784.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iv-v31n4p133-141.pdf","url":"https://iwate-u.repo.nii.ac.jp/record/9080/files/iv-v31n4p133-141.pdf"},"version_id":"d897c8c7-328d-4a57-80ca-5daf6e8094df"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"地方病性牛白血病リンパ腫細胞における腫瘍壊死因子受容体の発現に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"地方病性牛白血病リンパ腫細胞における腫瘍壊死因子受容体の発現に関する研究"}]},"item_type_id":"16","owner":"3","path":["1510"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-02-23"},"publish_date":"2009-02-23","publish_status":"0","recid":"9080","relation_version_is_last":true,"title":["地方病性牛白血病リンパ腫細胞における腫瘍壊死因子受容体の発現に関する研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T11:16:25.600301+00:00"}