| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2011-09-21 |
| タイトル |
|
|
タイトル |
Possible role of cysteine-S-conjugate β-lyase in species differences in cisplatin nephrotoxicity |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Cisplatin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Cysteine-S-conjugate β-lyase |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Nephrotoxicity |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Platinum |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Species difference |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Katayama, Rieko
Nagata, Saori
Iida, Hiroko
Yamagishi, Norio
Yamashita, Tetsuro
Furuhama, Kazuhisa
|
| 著者(機関) |
|
|
値 |
Department of Veterinary Basic Medicine, Iwate University, United Graduate School of Veterinary Sciences, Gifu University |
| 著者(機関) |
|
|
値 |
Department of Veterinary Basic Medicine, Iwate University |
| 著者(機関) |
|
|
値 |
Department of Veterinary Basic Medicine, Iwate University |
| 著者(機関) |
|
|
値 |
United Graduate School of Veterinary Sciences, Gifu University, Department of Veterinary Clinical Medicine, Iwate University |
| 著者(機関) |
|
|
値 |
Department of Food Science and Biochemistry, Faculty of Agriculture, Iwate University |
| 著者(機関) |
|
|
値 |
Department of Veterinary Basic Medicine,Iwate University, United Graduate School of Veterinary Sciences, Gifu University |
| 登録日 |
|
|
日付 |
2011-09-21 |
| 書誌情報 |
Food and Chemical Toxicology
巻 49,
号 9,
p. 2053-2059,
発行日 2011-09-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0278-6915 |
| Abstract |
|
|
内容記述タイプ |
Other |
|
内容記述 |
To better understand species differences in cisplatin nephrotoxicity, we focused on renal cysteine-S-conjugate β-lyase (C-S lyase), which may play a crucial role in the metabolism of platinum (Pt)-cysteine conjugates. Aminooxyacetic acid hemihydrochloride (AOAA), an inhibitor of C-S lyase, reduced renal injuries due to cisplatin in rats, suggesting involvement of C-S lyase. On day 5 following a bolus cisplatin injection, three species showed in vivo nephrotoxic potentials in the order of rats > mice = rabbits (the highest to lowest), based on body surface. The levels of renal Pt residue at the nephrotoxic dose were in order of rabbits > rats > mice. Meanwhile, the activity of endogenous (basal) mitochondrial aspartate aminotransferase (AST), one of the C-S lyases, in the renal cortex of naive animals was rats > mice = rabbits. In a qualitative Western blot analysis, expression of mitochondrial C-S lyase in the kidney was observed at approximately 37 kDa in all five species used. In in vitro studies, the cytotoxicity of cisplatin was dependent on the expression level of C-S lyase mRNA in the respective renal cells. These results demonstrate that species differences in cisplatin nephrotoxicity are attributable to an interaction of renal Pt transition with C-S lyase activity. |
| 出版者 |
|
|
出版者 |
Elsevier Ltd. |
| 権利 |
|
|
権利情報 |
Copyright © 2011 Elsevier Ltd. |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.fct.2011.05.017 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
fct-v49n9p2053-2059.pdf (451.6 kB)
