{"created":"2023-05-15T12:04:46.054813+00:00","id":9342,"links":{},"metadata":{"_buckets":{"deposit":"2da3fd6e-3dcb-4ec4-ba78-3141a49267af"},"_deposit":{"created_by":3,"id":"9342","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"9342"},"status":"published"},"_oai":{"id":"oai:iwate-u.repo.nii.ac.jp:00009342","sets":["1504:1510"]},"author_link":["72979","72980","72983","72984","72982","72981"],"item_16_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"708178(5)","bibliographicPageStart":"708178(1)","bibliographicVolumeNumber":"2012","bibliographic_titles":[{"bibliographic_title":"Advances in Pharmacological Sciences"}]}]},"item_16_date_6":{"attribute_name":"登録日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-10-09"}]},"item_16_description_12":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Anticholinesterases (antiChEs) are used to treat Alzheimer’s disease. The comparative effects of two antiChEs, methanesulfonyl fluoride (MSF) and donepezil, on the extracellular levels of ACh in the hippocampus were investigated by in vivo microdialysis in freely moving rats. MSF at 1 and 2 mg/kg produced a dose-dependent increase in ACh efflux from 10 min to at least 3 hrs after injection. At 2 mg/kg, the increase was still present at 24 hr. Donepezil at 1 mg/kg showed a similar but smaller effect, and, paradoxically, 2 mg/kg showed no consistent effect. MSF at 1 and 2 mg/kg decreased acetylcholinesterase activity in the hippocampus to 54.8 and 20.1% of control, respectively. These results suggest that MSF is a suitable candidate for the treatment of Alzheimer’s disease.","subitem_description_type":"Other"}]},"item_16_publisher_14":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Hindawi Publishing Corporation"}]},"item_16_relation_26":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1155/2012/708178","subitem_relation_type_select":"DOI"}}]},"item_16_rights_18":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2012 Tamotsu Imanishi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_16_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1687-6334","subitem_source_identifier_type":"ISSN"}]},"item_16_text_4":{"attribute_name":"著者(機関)","attribute_value_mlt":[{"subitem_text_value":"Department of Veterinary Medicine, Faculty of Agriculture, Iwate University,\n\nDepartment of Food Safety, Pharmaceutical and Medical Safety Bureau, Ministry of Health, Labour and Welfare"},{"subitem_text_value":"Department of Veterinary Medicine, Faculty of Agriculture, Iwate University,\n\nDepartment of Environmental and Occupational Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey"},{"subitem_text_value":"Department of Veterinary Medicine, Faculty of Agriculture, Iwate University"},{"subitem_text_value":"Department of Veterinary Medicine, Faculty of Agriculture, Iwate University,\n\nSciences of Cryobiosystems, United Graduate School of Agricultural Sciences of Iwate University"},{"subitem_text_value":"Department of Veterinary Medicine, Faculty of Agriculture, Iwate University"},{"subitem_text_value":"Department of Veterinary Medicine, Faculty of Agriculture, Iwate University"}]},"item_16_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Imanishi, Tamotsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hossain, Muhammad Mubarak"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Tadahiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Xu, Ping"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Itaru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, Haruo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-11-14"}],"displaytype":"detail","filename":"aps-v2012p708178.pdf","filesize":[{"value":"656.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"aps-v2012p708178.pdf","url":"https://iwate-u.repo.nii.ac.jp/record/9342/files/aps-v2012p708178.pdf"},"version_id":"eb62747d-6ad4-4dfa-804d-ec019e931fa0"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of a CNS-Sensitive Anticholinesterase Methane Sulfonyl Fluoride on Hippocampal Acetylcholine Release in Freely Moving Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of a CNS-Sensitive Anticholinesterase Methane Sulfonyl Fluoride on Hippocampal Acetylcholine Release in Freely Moving Rats"}]},"item_type_id":"16","owner":"3","path":["1510"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-09"},"publish_date":"2012-10-09","publish_status":"0","recid":"9342","relation_version_is_last":true,"title":["Effect of a CNS-Sensitive Anticholinesterase Methane Sulfonyl Fluoride on Hippocampal Acetylcholine Release in Freely Moving Rats"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T11:05:16.305767+00:00"}