{"created":"2023-05-15T12:04:48.586410+00:00","id":9386,"links":{},"metadata":{"_buckets":{"deposit":"5813c545-6f3f-49d4-95a4-2323a9133d8c"},"_deposit":{"created_by":3,"id":"9386","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"9386"},"status":"published"},"_oai":{"id":"oai:iwate-u.repo.nii.ac.jp:00009386","sets":["1504:1510"]},"author_link":["73290","73299","73295","73292","73287","73301","73297","73294","73298","73286","73288","73289","73293","73285","73296","73300","73302","73291"],"item_16_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageStart":"e88058","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"PLOS ONE"}]}]},"item_16_date_6":{"attribute_name":"登録日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-05-28"}]},"item_16_description_12":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"In mice, peripheral 5-HT induces an increase in the plasma concentrations of glucose, insulin and bile acids, and a decrease\nin plasma triglyceride, NEFA and cholesterol concentrations. However, given the unique characteristics of the metabolism of\nruminants relative to monogastric animals, the physiological role of peripheral 5-HT on glucose and lipid metabolism in\nsheep remains to be established. Therefore, in this study, we investigated the effect of 5-HT on the circulating\nconcentrations of metabolites and insulin using five 5-HT receptor (5HTR) antagonists in sheep. After fasting for 24 h, sheep\nwere intravenously injected with 5-HT, following which-, plasma glucose, insulin, triglyceride and NEFA concentrations were\nsignificantly elevated. In contrast, 5-HT did not affect the plasma cholesterol concentration, and it induced a decrease in bile\nacid concentrations. Increases in plasma glucose and insulin concentrations induced by 5-HT were attenuated by pretreatment\nwith Methysergide, a 5HTR 1, 2 and 7 antagonist. Additionally, decreased plasma bile acid concentrations induced\nby 5-HT were blocked by pre-treatment with Ketanserin, a 5HTR 2A antagonist. However, none of the 5HTR antagonists\ninhibited the increase in plasma triglyceride and NEFA levels induced by 5-HT. On the other hand, mRNA expressions of\n5HTR1D and 1E were observed in the liver, pancreas and skeletal muscle. These results suggest that there are a number of\ndifferences in the physiological functions of peripheral 5-HT with respect to lipid metabolism between mice and sheep,\nthough its effect on glucose metabolism appears to be similar between these species.","subitem_description_type":"Other"}]},"item_16_publisher_14":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_16_relation_26":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0088058","subitem_relation_type_select":"DOI"}}]},"item_16_rights_18":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"©2014 Watanabe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_16_text_4":{"attribute_name":"著者(機関)","attribute_value_mlt":[{"subitem_text_value":"Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University"},{"subitem_text_value":"Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University"},{"subitem_text_value":"Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University"},{"subitem_text_value":"Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University"},{"subitem_text_value":"Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University"},{"subitem_text_value":"Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University"},{"subitem_text_value":"Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University"},{"subitem_text_value":"Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University"},{"subitem_text_value":"Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University"},{"subitem_text_value":"Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University"},{"subitem_text_value":"Department of Animal Sciences, Faculty of Agriculture, Iwate University"},{"subitem_text_value":"Department of Animal Sciences, Faculty of Agriculture, Iwate University"},{"subitem_text_value":"Department of Animal Sciences, Faculty of Agriculture, Iwate University"},{"subitem_text_value":"Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University"},{"subitem_text_value":"Institute of Biological, Environmental and Rural Sciences, Aberystwyth University"},{"subitem_text_value":"Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University"},{"subitem_text_value":"Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University"},{"subitem_text_value":"Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University"}]},"item_16_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Watanabe, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Ryo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakano, Tatsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Hideyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Yu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sumiyoshi, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Katsuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chen, Xiangning"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okada, Natsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwasaki, Shunsuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Harjanti, Dian W."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sekiguchi, Natsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sano, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitazawa, Haruki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Rose, Michael T."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohwada, Shyuichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Kouichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aso, Hisashi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-11-14"}],"displaytype":"detail","filename":"ploso-v9i2pe88058.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ploso-v9i2pe88058.pdf","url":"https://iwate-u.repo.nii.ac.jp/record/9386/files/ploso-v9i2pe88058.pdf"},"version_id":"ec8f8ad5-4386-4dae-a51c-e02c6957c516"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of Peripheral 5-HT on Glucose and Lipid Metabolism in Wether Sheep","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of Peripheral 5-HT on Glucose and Lipid Metabolism in Wether Sheep"}]},"item_type_id":"16","owner":"3","path":["1510"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-05-28"},"publish_date":"2014-05-28","publish_status":"0","recid":"9386","relation_version_is_last":true,"title":["Effect of Peripheral 5-HT on Glucose and Lipid Metabolism in Wether Sheep"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T11:03:28.881226+00:00"}