{"created":"2023-05-15T12:05:09.927041+00:00","id":9784,"links":{},"metadata":{"_buckets":{"deposit":"4a7ec5ea-c69a-49fc-a096-6d182566ae21"},"_deposit":{"created_by":3,"id":"9784","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"9784"},"status":"published"},"_oai":{"id":"oai:iwate-u.repo.nii.ac.jp:00009784","sets":["1515:1519"]},"author_link":["60744","60743","60746","60742","60741","60745"],"item_16_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"769","bibliographicPageStart":"765","bibliographicVolumeNumber":"1790","bibliographic_titles":[{"bibliographic_title":"Biochimica et Biophysica Acta (BBA) - General Subjects"}]}]},"item_16_date_6":{"attribute_name":"登録日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-09-17"}]},"item_16_description_12":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Background: How neurons and neuronal circuits transform sensory input into behavior is not well\nunderstood. Because of its well-described, simple nervous system, Caenorhabditis elegans is an ideal model\norganism to study this issue. Transformation of sensory signals into neural activity is a crucial first step in the\nsensory–motor transformation pathway in an animal's nervous system. We examined the properties of\nchemosensory ASK neurons of C. elegans during sensory stimulation.\nMethod: A genetically encoded calcium sensor protein, G-CaMP, was expressed in ASK neurons of C. elegans,\nand the intracellular calcium dynamics of the neurons were observed.\nResults: After application of the attractants L-lysine or food-related stimuli, the level of calcium in ASK\nneurons decreased. In contrast, responses increased upon stimulus removal. Opposite responses were\nobserved after application and removal of a repellent.\nConclusion: The observed changes in response to external stimuli suggest that the activity of ASK neurons\nmay impact stimulus-evoked worm behavior. The stimulus-ON/activity-OFF properties of ASK neurons are\nsimilar to those of vertebrate retinal photoreceptors.\nGeneral significance: Analysis of sensory–motor transformation pathways based on the activity and structure\nof neuronal circuits is an important goal in neurobiology and is practical in C. elegans. Our study provides\ninsights into the mechanism of such transformation in the animal.","subitem_description_type":"Other"}]},"item_16_publisher_14":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"IEEE"}]},"item_16_relation_26":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbagen.2009.03.032","subitem_relation_type_select":"DOI"}}]},"item_16_rights_18":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2009 Elsevier B.V."}]},"item_16_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0304-4165","subitem_source_identifier_type":"ISSN"}]},"item_16_text_4":{"attribute_name":"著者(機関)","attribute_value_mlt":[{"subitem_text_value":"Laboratory of Bioscience, Faculty of Engineering, Iwate University"},{"subitem_text_value":"Laboratory of Bioscience, Faculty of Engineering, Iwate University"},{"subitem_text_value":"Laboratory of Bioscience, Faculty of Engineering, Iwate University"},{"subitem_text_value":"Laboratory of Bioscience, Faculty of Engineering, Iwate University"},{"subitem_text_value":"Department of Cell Biology and Functional Morphology, Iwate Medical University"},{"subitem_text_value":"Laboratory of Bioscience, Faculty of Engineering, Iwate University"}]},"item_16_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wakabayashi, Tokumitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kimura, Yukihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohba, Yusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Adachi, Ryota"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Satoh, Yoh-ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shingai, Ryuzo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-11-14"}],"displaytype":"detail","filename":"bbags-v1790i8p765-769.pdf","filesize":[{"value":"724.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bbags-v1790i8p765-769.pdf","url":"https://iwate-u.repo.nii.ac.jp/record/9784/files/bbags-v1790i8p765-769.pdf"},"version_id":"e7d22a35-7dbb-4339-abd0-dd1e29d5cd93"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"G-CaMP","subitem_subject_scheme":"Other"},{"subitem_subject":"calcium imaging","subitem_subject_scheme":"Other"},{"subitem_subject":"imaging","subitem_subject_scheme":"Other"},{"subitem_subject":"sensory neuron","subitem_subject_scheme":"Other"},{"subitem_subject":"OFF-response","subitem_subject_scheme":"Other"},{"subitem_subject":"L-lysine","subitem_subject_scheme":"Other"},{"subitem_subject":"SDS","subitem_subject_scheme":"Other"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"In vivo calcium imaging of OFF-responding ASK chemosensory neurons in C. elegans","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In vivo calcium imaging of OFF-responding ASK chemosensory neurons in C. elegans"}]},"item_type_id":"16","owner":"3","path":["1519"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-17"},"publish_date":"2009-09-17","publish_status":"0","recid":"9784","relation_version_is_last":true,"title":["In vivo calcium imaging of OFF-responding ASK chemosensory neurons in C. elegans"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T11:57:36.145622+00:00"}