| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-09-25 |
| タイトル |
|
|
タイトル |
Effect of cyclooxygenase-2 on the regulation of cerebral blood flow during neuronal activation in the rat |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Cerebral blood flow |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Cyclooxygenase-2 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Functional activation |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Laser-Doppler flowmetry |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Somatosensory stimulation |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Rat |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Matsuura, Tetsuya
Takuwa, Hiroyuki
Bakalova, Rumiana
Obata, Takayuki
Kanno, Iwao
|
| 著者(機関) |
|
|
値 |
Academic Group of Mathematical and Natural Science Iwate University, Department of Biophysics, Molecular Imaging Center, National Institute of Radiological Sciences |
| 著者(機関) |
|
|
値 |
Department of Biophysics, Molecular Imaging Center, National Institute of Radiological Sciences |
| 著者(機関) |
|
|
値 |
Department of Biophysics, Molecular Imaging Center, National Institute of Radiological Sciences |
| 著者(機関) |
|
|
値 |
Department of Biophysics, Molecular Imaging Center, National Institute of Radiological Sciences |
| 著者(機関) |
|
|
値 |
Department of Biophysics, Molecular Imaging Center, National Institute of Radiological Sciences |
| 登録日 |
|
|
日付 |
2009-09-25 |
| 書誌情報 |
Neuroscience Research
巻 65,
号 1,
p. 64-70,
発行日 2009-01-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0168-0102 |
| Abstract |
|
|
内容記述タイプ |
Other |
|
内容記述 |
The present study was designed to clarify the precision of the main approach for investigating the regulation of local cerebral blood flow (CBF) response to neuronal activation in the brain (neurovascular coupling). In this study, we examined the effects of NS-398, a highly selective cyclooxygenase-2 inhibitor, on the physiological variables, baseline CBF, and local CBF response during rat somatosensory neuronal activation by laser-Doppler flowmetry. Blood pressure and heart rate were significantly decreased 3 h after i.v. infusion of NS-398. Baseline CBF and local CBF during somatosensory activation gradually decreased with an increase in time of NS-398 infusion up to 3 h, although neuronal activity in the somatosensory area was almost constant during the infusion. The results suggest that cyclooxygenase-2 participates in the regulation of local CBF during neuronal activation in rats. The present study also revealed the potential side-effects of dimethylsulfoxide, a solvent of NS-398, on neurovascular coupling. |
| 出版者 |
|
|
出版者 |
Elsevier B.V. |
| 権利 |
|
|
権利情報 |
Copyright © 2009 Elsevier |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.neures.2009.05.006 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
nr-v65i1p64-70.pdf (471.6 kB)
