{"created":"2023-05-15T12:05:10.916109+00:00","id":9801,"links":{},"metadata":{"_buckets":{"deposit":"060a9a34-df5e-4d22-b5f0-71ccb45d73d1"},"_deposit":{"created_by":3,"id":"9801","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"9801"},"status":"published"},"_oai":{"id":"oai:iwate-u.repo.nii.ac.jp:00009801","sets":["1515:1519"]},"author_link":["60810","60811","60809"],"item_16_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"208","bibliographicPageStart":"201","bibliographicVolumeNumber":"51","bibliographic_titles":[{"bibliographic_title":"The Japanese Journal of Physiology"}]}]},"item_16_date_6":{"attribute_name":"登録日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-10-13"}]},"item_16_description_12":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"We measured the field potential and the changes in local cerebral blood flow (LCBF) response during somatosensory activation (evoked LCBF) in α-chloralose-anesthetized rats by laser-Doppler flowmetry under normocapnia (PaCO2=34.3±3.8 mmHg) and hypercapnia (PaCO2=70.1±9.8 mmHg). Somatosensory activation was induced by electrical stimulation (0.2, 1, and 5 Hz with 1.5 mA for 5 s) of the hind paw. The neuronal activity of the somatosensory area of the hind paw was linear to the stimulus frequency, and there was no significant difference in the neuronal activity between hypercapnia and normocapnia. The baseline level of LCBF under hypercapnia was about 72.2% higher than that under normocapnia (p<0.01). The absolute response magnitude under hypercapnia was greater than that under normocapnia (p<0.05). The evoked LCBF under both conditions showed a frequency-dependent increase in the 0.2 to 5 Hz range, and the difference in the absolute response magnitude at the same stimulus frequency between normocapnia and hypercapnia became large with increasing stimulus frequency (p<0.05). On the other hand, after normalization to each baseline level there was no significant difference in the response magnitude of the normalized evoked LCBF between normocapnia and hypercapnia, indicating that the normalized evoked LCBF reflects neuronal activity even when the baseline LCBF was changed by the PaCO2 level. The peak time and termination time of LCBF response curves with respect to the graded neuronal activity at 1 and 5 Hz stimulation increased significantly under hypercapnia, compared with those under normocapnia (p<0.05), although the rise time of 0.5 s was nearly constant. In conclusion, the results suggest a synergistic effect of the combined application of graded neuronal stimuli and hypercapnia on the LCBF response.","subitem_description_type":"Other"}]},"item_16_publisher_14":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本生理学会"}]},"item_16_relation_26":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2170/jjphysiol.51.201","subitem_relation_type_select":"DOI"}}]},"item_16_rights_18":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2001 日本生理学会"}]},"item_16_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-521X","subitem_source_identifier_type":"ISSN"}]},"item_16_text_4":{"attribute_name":"著者(機関)","attribute_value_mlt":[{"subitem_text_value":"Department of Radiology and Nuclear Medicine, Akita Research Institute for Brain and Blood Vessels,(Present address): Department of Welfare Engineering, Faculty of Engineering, Iwate University"},{"subitem_text_value":"Akita Laboratory, Japan Science and Technology Corporation,Akita Research Institute for Brain and Blood Vessels"},{"subitem_text_value":"Department of Radiology and Nuclear Medicine, Akita Research Institute for Brain and Blood Vessels,(Present address): National Institute of Radiological Sciences, Japan"}]},"item_16_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Bakalova, Roumiana"}],"nameIdentifiers":[{"nameIdentifier":"60809","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuura, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"60810","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanno, Iwao"}],"nameIdentifiers":[{"nameIdentifier":"60811","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-11-14"}],"displaytype":"detail","filename":"jjp-v51n2p201-208.pdf","filesize":[{"value":"101.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jjp-v51n2p201-208.pdf","url":"https://iwate-u.repo.nii.ac.jp/record/9801/files/jjp-v51n2p201-208.pdf"},"version_id":"aee96023-927f-4c77-bce2-83dd26360f54"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cerebral blood flow","subitem_subject_scheme":"Other"},{"subitem_subject":"hind paw stimulation","subitem_subject_scheme":"Other"},{"subitem_subject":"hypercapnia","subitem_subject_scheme":"Other"},{"subitem_subject":"somatosensory cortex","subitem_subject_scheme":"Other"},{"subitem_subject":"laser-Doppler flowmetry","subitem_subject_scheme":"Other"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Frequency Dependence of Local Cerebral Blood Flow Induced by Somatosensory Hind Paw Stimulation in Rat under Normo- and Hypercapnia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Frequency Dependence of Local Cerebral Blood Flow Induced by Somatosensory Hind Paw Stimulation in Rat under Normo- and Hypercapnia"}]},"item_type_id":"16","owner":"3","path":["1519"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-10-13"},"publish_date":"2009-10-13","publish_status":"0","recid":"9801","relation_version_is_last":true,"title":["Frequency Dependence of Local Cerebral Blood Flow Induced by Somatosensory Hind Paw Stimulation in Rat under Normo- and Hypercapnia"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T11:56:53.585782+00:00"}