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Changes in Red Blood Cell Behavior during Cerebral Blood Flow Increase in the Rat Somatosensory Cortex: A Study of Laser-Doppler Flowmetry
https://iwate-u.repo.nii.ac.jp/records/9802
https://iwate-u.repo.nii.ac.jp/records/980206e2650e-d70b-44ba-9469-9505b9fd4389
| 名前 / ファイル | ライセンス | アクション |
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jjp-v51n6p703-708.pdf (72.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2009-10-13 | |||||||||
| タイトル | ||||||||||
| タイトル | Changes in Red Blood Cell Behavior during Cerebral Blood Flow Increase in the Rat Somatosensory Cortex: A Study of Laser-Doppler Flowmetry | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | cerebral blood flow | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | hypercapnia | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | laser-Doppler flowmetry | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | somatosensory stimulation | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | rat | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Matsuura, Tetsuya
× Matsuura, Tetsuya
× Kanno, Iwao
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| 著者(機関) | ||||||||||
| 値 | Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels,(Present address): Department of Welfare Engineering, Faculty of Engineering, Iwate University | |||||||||
| 著者(機関) | ||||||||||
| 値 | Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels,(Present address): National Institute of Radiological Sciences, Japan | |||||||||
| 登録日 | ||||||||||
| 日付 | 2009-10-13 | |||||||||
| 書誌情報 |
The Japanese Journal of Physiology 巻 51, 号 6, p. 703-708, 発行日 2001-01-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0021-521X | |||||||||
| Abstract | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | The purpose of this study was to investigate red blood cell (RBC) behavior during an increase in local cerebral blood flow (LCBF). We measured changes in RBC behavior by using laser-Doppler flowmetry (LDF) in &agr;-chloralose-anesthetized rats. An increase in LCBF was carried out by approximately 2.5 and 4.0% CO2 inhalation and activation of the somatosensory cortex. The activation of the cortex was induced by electrical stimulation of the hind paw with 1.5-mA pulses (0.1 ms) applied at frequencies of 0.2, 1, 5, and 10 Hz for a 5 s duration. The increases in LCBF and RBC velocity during both CO2 inhalations were larger than that in RBC concentration (p < 0.05). LCBF and RBC velocity during 4.0% CO2 inhalation were larger than those during 2.5% CO2 inhalation (p < 0.05), though there was no significant difference in RBC concentration between the two conditions, suggesting a limitation of capillary volume. During somatosensory stimulation, the evoked LCBF increased with increasing stimulus frequency up to 5 Hz and decreased at 10 Hz. The responses of RBC concentration at 0.2 and 10 Hz were greater than those of RBC velocity (p < 0.05), but no significant differences in response magnitude were found at 1 and 5 Hz between RBC concentration and RBC velocity. These results suggest that the increase in LCBF during neuronal activity is different from that of controlling the LCBF as induced by CO2, and that the regulation of RBC concentration and RBC velocity is controlled by independent mechanisms. | |||||||||
| 出版者 | ||||||||||
| 出版者 | 日本生理学会 | |||||||||
| 権利 | ||||||||||
| 権利情報 | Copyright (c) 2001 日本生理学会 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.2170/jjphysiol.51.703 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
