Faculty of Applied Biological Sciences, Gifu University
The United Graduate School of Veterinary Sciences, Gifu University
Faculty of Applied Biological Sciences, Gifu University , The United Graduate School of Veterinary Sciences, Gifu University , Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University
Faculty of Agriculture, Iwate University
Joint Faculty of Veterinary Medicine, Kagoshima University
Faculty of Applied Biological Sciences, Gifu University
Faculty of Applied Biological Sciences, Gifu University , The United Graduate School of Veterinary Sciences, Gifu University
Faculty of Applied Biological Sciences, Gifu University , The United Graduate School of Veterinary Sciences, Gifu University
Joint Faculty of Veterinary Medicine, Kagoshima University
Faculty of Applied Biological Sciences, Gifu University , The United Graduate School of Veterinary Sciences, Gifu University , Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University
登録日
2022-08-30
雑誌名
Veterinary Sciences
巻
8
号
9
ページ
192
発行年
2021-09-12
ISSN
23067381
抄録
Canine degenerative myelopathy (DM), recognized as a spontaneous model of amyotrophic lateral sclerosis, is known as a late-onset progressive degenerative disease of the spinal cord. Because of the progressive nature of DM, many dogs are elected to be euthanized, resulting in limited information on the end-stage clinical presentation. We investigated the long-term clinical course from diagnosis to natural death to further deepen our understanding of the entire clinical picture of this disease. Because curcumin was administered in some cases, the therapeutic effect of curcumin on DM was also examined. Forty dogs included in this study were client-owned Pembroke Welsh Corgis with a definitive diagnosis of DM by necropsy and histopathology. Dogs were excluded from this study if they died from another disease or were elected to be euthanized. Information on the long-term clinical symptoms of DM was investigated based on a questionnaire, which was collected from the dog owners. Urinary incontinence and respiratory disorder were observed in most dogs, as was respiratory impairment-correlated death. In contrast, signs consistent with brainstem dysfunction were noticed at the terminal stage in a small portion of dogs. Although further studies with more cases are needed, the results of this study suggest that administration of curcumin is effective in slowing the progression of DM.
The long-term clinical course of canine degenerative myelopathy and therapeutic potential of curcumin
vs-v8n9p192
(1.19MB)
