| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-08-30 |
| タイトル |
|
|
タイトル |
The long-term clinical course of canine degenerative myelopathy and therapeutic potential of curcumin |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
amyotrophic lateral sclerosis |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
curcumin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
degenerative myelopathy |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
dogs |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
KOBATAKE, Yui
NAKATA, Kohei
SAKAI, Hiroki
SASAKI, Jun
YAMATO, Osamu
TAKASHIMA, Satoshi
NISHII, Naohito
MAEDA, Sadatoshi
ISLAM, Md Shafiqul
KAMISHINA, Hiroaki
|
| 著者(機関) |
|
|
値 |
Faculty of Applied Biological Sciences, Gifu University |
| 著者(機関) |
|
|
値 |
The United Graduate School of Veterinary Sciences, Gifu University |
| 著者(機関) |
|
|
値 |
Faculty of Applied Biological Sciences, Gifu University , The United Graduate School of Veterinary Sciences, Gifu University , Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University |
| 著者(機関) |
|
|
値 |
Faculty of Agriculture, Iwate University |
| 著者(機関) |
|
|
値 |
Joint Faculty of Veterinary Medicine, Kagoshima University |
| 著者(機関) |
|
|
値 |
Faculty of Applied Biological Sciences, Gifu University |
| 著者(機関) |
|
|
値 |
Faculty of Applied Biological Sciences, Gifu University , The United Graduate School of Veterinary Sciences, Gifu University |
| 著者(機関) |
|
|
値 |
Faculty of Applied Biological Sciences, Gifu University , The United Graduate School of Veterinary Sciences, Gifu University |
| 著者(機関) |
|
|
値 |
Joint Faculty of Veterinary Medicine, Kagoshima University |
| 著者(機関) |
|
|
値 |
Faculty of Applied Biological Sciences, Gifu University , The United Graduate School of Veterinary Sciences, Gifu University , Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University |
| 登録日 |
|
|
日付 |
2022-08-30 |
| 書誌情報 |
Veterinary Sciences
巻 8,
号 9,
p. 192,
発行日 2021-09-12
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
23067381 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Canine degenerative myelopathy (DM), recognized as a spontaneous model of amyotrophic lateral sclerosis, is known as a late-onset progressive degenerative disease of the spinal cord. Because of the progressive nature of DM, many dogs are elected to be euthanized, resulting in limited information on the end-stage clinical presentation. We investigated the long-term clinical course from diagnosis to natural death to further deepen our understanding of the entire clinical picture of this disease. Because curcumin was administered in some cases, the therapeutic effect of curcumin on DM was also examined. Forty dogs included in this study were client-owned Pembroke Welsh Corgis with a definitive diagnosis of DM by necropsy and histopathology. Dogs were excluded from this study if they died from another disease or were elected to be euthanized. Information on the long-term clinical symptoms of DM was investigated based on a questionnaire, which was collected from the dog owners. Urinary incontinence and respiratory disorder were observed in most dogs, as was respiratory impairment-correlated death. In contrast, signs consistent with brainstem dysfunction were noticed at the terminal stage in a small portion of dogs. Although further studies with more cases are needed, the results of this study suggest that administration of curcumin is effective in slowing the progression of DM. |
| 抄録（URL） |
|
|
表示名 |
The Long-Term Clinical Course of Canine Degenerative Myelopathy and Therapeutic Potential of Curcumin |
|
URL |
https://www.mdpi.com/2306-7381/8/9/192 |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利 |
|
|
権利情報 |
© 2021 by the authors. |
| 権利URI |
|
|
権利情報 |
https://creativecommons.org/licenses/by/4.0/ |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
info:doi/10.3390/vetsci8090192 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
vs-v8n9p192 (1.2 MB)
