| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-01-04 |
| タイトル |
|
|
タイトル |
CXCL5-CXCR2 signaling is a senescence-associated secretory phenotype in preimplantation embryos |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
aging |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
CXCL5 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
CXCR2 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
infertility |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
preimplantation embryo |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
SASP |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
KAWAGOE, Yuta
KAWASHIMA, Ikko
SATO, Yorino
OKAMOTO, Naoki
MATSUBARA, Kazuei
KAWAMURA, Kazuhiro
|
| 著者(機関) |
|
|
値 |
Department of Obstetrics and Gynecology, Advanced Reproduction Research Center, International University of Health and Welfare School of Medicine, The United Graduate School of Agriculture Sciences, Iwate University |
| 著者(機関) |
|
|
値 |
Institute of Advanced BioMedical Engineering and Science, Tokyo Women's Medical University |
| 著者(機関) |
|
|
値 |
Department of Obstetrics and Gynecology, Advanced Reproduction Research Center, International University of Health and Welfare School of Medicine |
| 著者(機関) |
|
|
値 |
Department of Obstetrics and Gynecology, Advanced Reproduction Research Center, International University of Health and Welfare School of Medicine |
| 著者(機関) |
|
|
値 |
The United Graduate School of Agriculture Sciences, Iwate University |
| 著者(機関) |
|
|
値 |
Department of Obstetrics and Gynecology, Advanced Reproduction Research Center, International University of Health and Welfare School of Medicine |
| 登録日 |
|
|
日付 |
2022-01-04 |
| 書誌情報 |
Aging Cell
巻 19,
号 10,
p. e13240,
発行日 2020-09-22
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14749726 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Pregnancy rate of women decreases with age due to declining quality of oocytes and embryos. However, there is no established method to improve pregnancy rate in aging women. In this study, we identified a senescence-associated secretory phenotype (SASP) factor partially responsible for the decline in embryo implantation potential. Based on microarray analysis using young and aging human embryos at the same morphological grade, 702 genes showed >fivefold increases in aging human blastocysts. Among these genes, C-X-C motif chemokine 5 (CXCL5) showed 7.7-fold increases in aging human blastocysts. However, no-age-dependent changes in expression of the CXCR2, the cognate receptor for CXCL5, were found. In aging mice, Cxcl5 transcript levels were also increased in oocytes and embryos. Treatment of young mouse embryos with CXCL5 decreased implantation rates, together with increased expression of aging markers (P53, P21, Pai-1, and Il-6). Moreover, CXCL5 treatment suppressed trophoblast outgrowth in young mouse blastocysts. Conversely, suppression of CXCL5-CXCR2 signaling in aging mouse embryos using neutralizing antibodies and a receptor antagonist improved the implantation rate, leading to increases in pregnancy and delivery of normal pups. The gene expression pattern of these embryos was comparable to that in young mouse embryos showing enriched cell proliferation-related pathways. In conclusion, we identified CXCL5 as a SASP factor in human and mouse embryos and suppression of CXCL5-CXCR2 signaling during embryo culture improved pregnancy success in aging mice. Future analysis on CXCL5-CXCR2 signaling suppression in human embryos could be the basis to improve embryo development and pregnancy outcome in middle-aged infertile patients. |
| 出版者 |
|
|
出版者 |
Wiley |
| 関係URI |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://onlinelibrary.wiley.com/doi/10.1111/acel.13240 |
|
|
関連名称 |
CXCL5-CXCR2 signaling is a senescence-associated secretory phenotype in preimplantation embryos |
| 権利 |
|
|
権利情報 |
© 2020 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd |
| 権利URI |
|
|
権利情報 |
http://creativecommons.org/licenses/by/4.0/ |
| NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12097741 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
info:doi/10.1111/acel.13240 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
ac-v19n10pe13240 (1.5 MB)
