| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-08-26 |
| タイトル |
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タイトル |
A novel cyclic peptide (Naturido) modulates glia–neuron interactions in vitro and reverses ageing-related deficits in senescence-accelerated mice |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
ISHIGURO, Shinichi
SHINADA, Tetsuro
WU, Zhou
KARIMAZAWA, Mayumi
UCHIDATE, Michimasa
NISHIMURA, Eiji
YASUNO, Yoko
EBATA, Makiko
SILLAPAKONG, Piyamas
ISHIGURO, Hiromi
EBATA, Nobuyoshi
NI, Junjun
JIANG, Muzhou
GORYO, Masanobu
OTSU, Keishi
HARADA, Hidemitsu
SUZUKI, Koichi
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| 著者(機関) |
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値 |
Biococoon Laboratories, Inc. |
| 著者(機関) |
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値 |
Graduate School of Science, Osaka City University |
| 著者(機関) |
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値 |
Faculty of Dental Science, Department of Aging Science and Pharmacology, Kyushu University , Faculty of Dental Science, OBT Research Center, Kyushu University |
| 著者(機関) |
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値 |
Biococoon Laboratories, Inc. |
| 著者(機関) |
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値 |
Faculty of Science and Engineering, Iwate University |
| 著者(機関) |
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値 |
Graduate School of Science, Osaka City University |
| 著者(機関) |
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値 |
Graduate School of Science, Osaka City University |
| 著者(機関) |
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値 |
Biococoon Laboratories, Inc. |
| 著者(機関) |
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値 |
Biococoon Laboratories, Inc. |
| 著者(機関) |
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値 |
Biococoon Laboratories, Inc. |
| 著者(機関) |
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値 |
Biococoon Laboratories, Inc. |
| 著者(機関) |
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値 |
Faculty of Dental Science, Department of Aging Science and Pharmacology, Kyushu University |
| 著者(機関) |
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値 |
Faculty of Dental Science, Department of Aging Science and Pharmacology, Kyushu University |
| 著者(機関) |
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値 |
Iwate University |
| 著者(機関) |
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値 |
Division of Developmental Biology and Regenerative Medicine, Department of Anatomy, Iwate Medical University |
| 著者(機関) |
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値 |
Division of Developmental Biology and Regenerative Medicine, Department of Anatomy, Iwate Medical University |
| 著者(機関) |
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値 |
Biococoon Laboratories, Inc. |
| 登録日 |
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日付 |
2022-08-26 |
| 書誌情報 |
PLoS ONE
巻 16,
号 1,
p. e0245235,
発行日 2021-01-27
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
19326203 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The use of agents that target both glia and neurons may represent a new strategy for the treatment of ageing disorders. Here, we confirmed the presence of the novel cyclic peptide Naturido that originates from a medicinal fungus (Isaria japonica) grown on domestic silkworm (Bombyx mori). We found that Naturido significantly enhanced astrocyte proliferation and activated the single copy gene encoding the neuropeptide VGF and the neuron-derived NGF gene. The addition of the peptide to the culture medium of primary hippocampal neurons increased dendrite length, dendrite number and axon length. Furthermore, the addition of the peptide to primary microglial cultures shifted CGA-activated microglia towards anti-inflammatory and neuroprotective phenotypes. These findings of in vitro glia–neuron interactions led us to evaluate the effects of oral administration of the peptide on brain function and hair ageing in senescence-accelerated mice (SAMP8). In vivo analyses revealed that spatial learning ability and hair quality were improved in Naturido-treated mice compared with untreated mice, to the same level observed in the normal ageing control (SAMR1). These data suggest that Naturido may be a promising glia–neuron modulator for the treatment of not only senescence, but also Alzheimer’s disease and other neurodegenerative diseases. |
| 抄録（URL） |
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|
表示名 |
A novel cyclic peptide (Naturido) modulates glia–neuron interactions in vitro and reverses ageing-related deficits in senescence-accelerated mice |
|
URL |
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0245235 |
| 出版者 |
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出版者 |
Public Library of Science |
| 権利 |
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権利情報 |
© 2021 Ishiguro et al. |
| 権利URI |
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権利情報 |
https://creativecommons.org/licenses/by/4.0/ |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
info:doi/10.1371/journal.pone.0245235 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
ploso-v16n1e0245235 (1.9 MB)
