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  1. 030 理工学 Science ＆ engineering
  2. 学術雑誌掲載論文

A novel cyclic peptide (Naturido) modulates glia–neuron interactions in vitro and reverses ageing-related deficits in senescence-accelerated mice

https://iwate-u.repo.nii.ac.jp/records/15773
https://iwate-u.repo.nii.ac.jp/records/15773
1c303884-fc84-4903-a073-ef21d8c1e27a
名前 / ファイル ライセンス アクション
ploso-v16n1e0245235.pdf ploso-v16n1e0245235 (1.9 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2022-08-26
タイトル
タイトル A novel cyclic peptide (Naturido) modulates glia–neuron interactions in vitro and reverses ageing-related deficits in senescence-accelerated mice
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 ISHIGURO, Shinichi

× ISHIGURO, Shinichi

ISHIGURO, Shinichi
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SHINADA, Tetsuro

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SHINADA, Tetsuro
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WU, Zhou

× WU, Zhou

WU, Zhou
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KARIMAZAWA, Mayumi

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KARIMAZAWA, Mayumi
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UCHIDATE, Michimasa

× UCHIDATE, Michimasa

UCHIDATE, Michimasa
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NISHIMURA, Eiji

× NISHIMURA, Eiji

NISHIMURA, Eiji
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YASUNO, Yoko

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YASUNO, Yoko
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EBATA, Makiko

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EBATA, Makiko
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SILLAPAKONG, Piyamas

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SILLAPAKONG, Piyamas
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ISHIGURO, Hiromi

× ISHIGURO, Hiromi

ISHIGURO, Hiromi
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EBATA, Nobuyoshi

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EBATA, Nobuyoshi
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NI, Junjun

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NI, Junjun
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JIANG, Muzhou

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JIANG, Muzhou
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GORYO, Masanobu

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GORYO, Masanobu
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OTSU, Keishi

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OTSU, Keishi
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HARADA, Hidemitsu

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HARADA, Hidemitsu
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SUZUKI, Koichi

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SUZUKI, Koichi
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著者(機関)
値 Biococoon Laboratories, Inc.
著者(機関)
値 Graduate School of Science, Osaka City University
著者(機関)
値 Faculty of Dental Science, Department of Aging Science and Pharmacology, Kyushu University , Faculty of Dental Science, OBT Research Center, Kyushu University
著者(機関)
値 Biococoon Laboratories, Inc.
著者(機関)
値 Faculty of Science and Engineering, Iwate University
著者(機関)
値 Graduate School of Science, Osaka City University
著者(機関)
値 Graduate School of Science, Osaka City University
著者(機関)
値 Biococoon Laboratories, Inc.
著者(機関)
値 Biococoon Laboratories, Inc.
著者(機関)
値 Biococoon Laboratories, Inc.
著者(機関)
値 Biococoon Laboratories, Inc.
著者(機関)
値 Faculty of Dental Science, Department of Aging Science and Pharmacology, Kyushu University
著者(機関)
値 Faculty of Dental Science, Department of Aging Science and Pharmacology, Kyushu University
著者(機関)
値 Iwate University
著者(機関)
値 Division of Developmental Biology and Regenerative Medicine, Department of Anatomy, Iwate Medical University
著者(機関)
値 Division of Developmental Biology and Regenerative Medicine, Department of Anatomy, Iwate Medical University
著者(機関)
値 Biococoon Laboratories, Inc.
登録日
日付 2022-08-26
書誌情報 PLoS ONE

巻 16, 号 1, p. e0245235, 発行日 2021-01-27
ISSN
収録物識別子タイプ ISSN
収録物識別子 19326203
抄録
内容記述タイプ Abstract
内容記述 The use of agents that target both glia and neurons may represent a new strategy for the treatment of ageing disorders. Here, we confirmed the presence of the novel cyclic peptide Naturido that originates from a medicinal fungus (Isaria japonica) grown on domestic silkworm (Bombyx mori). We found that Naturido significantly enhanced astrocyte proliferation and activated the single copy gene encoding the neuropeptide VGF and the neuron-derived NGF gene. The addition of the peptide to the culture medium of primary hippocampal neurons increased dendrite length, dendrite number and axon length. Furthermore, the addition of the peptide to primary microglial cultures shifted CGA-activated microglia towards anti-inflammatory and neuroprotective phenotypes. These findings of in vitro glia–neuron interactions led us to evaluate the effects of oral administration of the peptide on brain function and hair ageing in senescence-accelerated mice (SAMP8). In vivo analyses revealed that spatial learning ability and hair quality were improved in Naturido-treated mice compared with untreated mice, to the same level observed in the normal ageing control (SAMR1). These data suggest that Naturido may be a promising glia–neuron modulator for the treatment of not only senescence, but also Alzheimer’s disease and other neurodegenerative diseases.
抄録（URL）
表示名 A novel cyclic peptide (Naturido) modulates glia–neuron interactions in vitro and reverses ageing-related deficits in senescence-accelerated mice
URL https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0245235
出版者
出版者 Public Library of Science
権利
権利情報 © 2021 Ishiguro et al.
権利URI
権利情報 https://creativecommons.org/licenses/by/4.0/
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 info:doi/10.1371/journal.pone.0245235
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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