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  1. 010 人文社会 Humanities & Social Sciences
  2. 01 学術雑誌掲載論文

Utility of urinary albumin excretion as an index for stratifying the residual cardiovascular risk in patients undergoing antihypertensive agents treatment

https://iwate-u.repo.nii.ac.jp/records/15775
https://iwate-u.repo.nii.ac.jp/records/15775
82b6ab68-cd73-4e4a-8d2e-2f35875b082b
名前 / ファイル ライセンス アクション
jht-v39n12p2431-2438.pdf jht-v39n12p2431-2438 (581.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2022-08-29
タイトル
タイトル Utility of urinary albumin excretion as an index for stratifying the residual cardiovascular risk in patients undergoing antihypertensive agents treatment
言語
言語 eng
キーワード
主題Scheme Other
主題 blood pressure
キーワード
主題Scheme Other
主題 cardiovascular
キーワード
主題Scheme Other
主題 hypertension
キーワード
主題Scheme Other
主題 urinary albumin
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 KIKUCHI, Yawara

× KIKUCHI, Yawara

WEKO 95033

KIKUCHI, Yawara

Search repository
TANAKA, Fumitaka

× TANAKA, Fumitaka

WEKO 95034

TANAKA, Fumitaka

Search repository
NAKAMURA, Motoyuki

× NAKAMURA, Motoyuki

WEKO 95035

NAKAMURA, Motoyuki

Search repository
TANNO, Kozo

× TANNO, Kozo

WEKO 95036

TANNO, Kozo

Search repository
ONODA, Toshiyuki

× ONODA, Toshiyuki

WEKO 95037

ONODA, Toshiyuki

Search repository
OHSAWA, Masaki

× OHSAWA, Masaki

WEKO 95038

OHSAWA, Masaki

Search repository
SAKATA, Kiyomi

× SAKATA, Kiyomi

WEKO 95039

SAKATA, Kiyomi

Search repository
OMAMA, Shinichi

× OMAMA, Shinichi

WEKO 95040

OMAMA, Shinichi

Search repository
OGASAWARA, Kuniaki

× OGASAWARA, Kuniaki

WEKO 95041

OGASAWARA, Kuniaki

Search repository
YONEKURA, Yuki

× YONEKURA, Yuki

WEKO 95042

YONEKURA, Yuki

Search repository
ITAI, Kazuyoshi

× ITAI, Kazuyoshi

WEKO 95043

ITAI, Kazuyoshi

Search repository
KURIBAYASHI, Toru

× KURIBAYASHI, Toru

WEKO 95044

KURIBAYASHI, Toru

Search repository
ISHIGAKI, Yasushi

× ISHIGAKI, Yasushi

WEKO 95045

ISHIGAKI, Yasushi

Search repository
OKAYAMA, Akira

× OKAYAMA, Akira

WEKO 95046

OKAYAMA, Akira

Search repository
ASAHI, Koichi

× ASAHI, Koichi

WEKO 95047

ASAHI, Koichi

Search repository
著者(機関)
Department of Internal Medicine
著者(機関)
Department of Internal Medicine
著者(機関)
Department of Internal Medicine
著者(機関)
Department of Hygiene and Preventive Medicine
著者(機関)
Department of Hygiene and Preventive Medicine
著者(機関)
Department of Internal Medicine
著者(機関)
Department of Hygiene and Preventive Medicine
著者(機関)
Department of Neurosurgery, Iwate Medical University
著者(機関)
Department of Neurosurgery, Iwate Medical University
著者(機関)
St. Luke's International University
著者(機関)
Department of Nutritional Sciences, Morioka University
著者(機関)
Faculty of Humanities and Social Sciences, Iwate University
著者(機関)
Department of Internal Medicine
著者(機関)
Research Institute of Strategy for Prevention
著者(機関)
Department of Internal Medicine
登録日
日付 2022-08-29
書誌情報 Journal of hypertension

巻 39, 号 12, p. 2431-2438, 発行日 2021
ISSN
収録物識別子タイプ ISSN
収録物識別子 14735598
抄録
内容記述タイプ Abstract
内容記述 Background: Patients treated with antihypertensive medication, even those with well controlled blood pressure (BP), are at higher risk for the development of atherosclerotic cardiovascular disease (ASCVD) in comparison to nonhypertensive individuals with optimal risk levels. We hypothesized that this residual risk could be stratified based on urinary albumin excretion (UAE).
Methods: A total of 13 082 middle-aged and older individuals with SBP/DBP of less than 160/100 mmHg and urinary albumin-to-creatinine ratios (UACRs) of less than 300 mg/g, and who were free from ASCVD events, were followed to investigate the incidence of ASCVD. The baseline BP was classified into four categories: normal BP (BP1), high normal BP (BP2), elevated BP (BP3), and grade 1 hypertension (BP4) based on the 2019 Japanese Society of Hypertension guidelines.
Results: After an average 10.6 ± 2.6 years of follow-up, the multivariable hazard ratio for the development of ASCVD (n = 994) was already increased in medicated hypertensive patients with BP1 in comparison with untreated individuals with BP1; however, among medicated hypertensive patients, this risk was separated between the UAE groups, which were classified according to the median UACR (male, 15.4 mg/g; female, 19.0 mg/g). In medicated hypertensive patients with any category of BP1-BP3, the adjusted risk of the development of ASCVD in those with lower and higher UACRs was comparable to that observed in untreated individuals in the BP1 and BP4 categories, respectively.
Conclusion: In medicated patients with well controlled hypertension, UAE is useful for stratifying the residual risk of developing ASCVD in comparison to nonhypertensive individuals with optimal risk levels.
抄録(URL)
Utility of urinary albumin excretion as an index for stratifying the residual cardiovascular risk in patients undergoing antihypertensive agents treatment
https://journals.lww.com/jhypertension/Fulltext/2021/12000/Utility_of_urinary_albumin_excretion_as_an_index.12.aspx
出版者
出版者 Wolters Kluwer Health, Inc.
権利
権利情報 © 2021 The Author(s).
権利URI
権利情報 https://creativecommons.org/licenses/by-nc-nd/4.0/
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 info:doi/10.1097/HJH.0000000000002947
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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