| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-08-29 |
| タイトル |
|
|
タイトル |
Utility of urinary albumin excretion as an index for stratifying the residual cardiovascular risk in patients undergoing antihypertensive agents treatment |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
blood pressure |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
cardiovascular |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
hypertension |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
urinary albumin |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
KIKUCHI, Yawara
TANAKA, Fumitaka
NAKAMURA, Motoyuki
TANNO, Kozo
ONODA, Toshiyuki
OHSAWA, Masaki
SAKATA, Kiyomi
OMAMA, Shinichi
OGASAWARA, Kuniaki
YONEKURA, Yuki
ITAI, Kazuyoshi
KURIBAYASHI, Toru
ISHIGAKI, Yasushi
OKAYAMA, Akira
ASAHI, Koichi
|
| 著者(機関) |
|
|
値 |
Department of Internal Medicine |
| 著者(機関) |
|
|
値 |
Department of Internal Medicine |
| 著者(機関) |
|
|
値 |
Department of Internal Medicine |
| 著者(機関) |
|
|
値 |
Department of Hygiene and Preventive Medicine |
| 著者(機関) |
|
|
値 |
Department of Hygiene and Preventive Medicine |
| 著者(機関) |
|
|
値 |
Department of Internal Medicine |
| 著者(機関) |
|
|
値 |
Department of Hygiene and Preventive Medicine |
| 著者(機関) |
|
|
値 |
Department of Neurosurgery, Iwate Medical University |
| 著者(機関) |
|
|
値 |
Department of Neurosurgery, Iwate Medical University |
| 著者(機関) |
|
|
値 |
St. Luke's International University |
| 著者(機関) |
|
|
値 |
Department of Nutritional Sciences, Morioka University |
| 著者(機関) |
|
|
値 |
Faculty of Humanities and Social Sciences, Iwate University |
| 著者(機関) |
|
|
値 |
Department of Internal Medicine |
| 著者(機関) |
|
|
値 |
Research Institute of Strategy for Prevention |
| 著者(機関) |
|
|
値 |
Department of Internal Medicine |
| 登録日 |
|
|
日付 |
2022-08-29 |
| 書誌情報 |
Journal of hypertension
巻 39,
号 12,
p. 2431-2438,
発行日 2021
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14735598 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Patients treated with antihypertensive medication, even those with well controlled blood pressure (BP), are at higher risk for the development of atherosclerotic cardiovascular disease (ASCVD) in comparison to nonhypertensive individuals with optimal risk levels. We hypothesized that this residual risk could be stratified based on urinary albumin excretion (UAE).
Methods: A total of 13 082 middle-aged and older individuals with SBP/DBP of less than 160/100 mmHg and urinary albumin-to-creatinine ratios (UACRs) of less than 300 mg/g, and who were free from ASCVD events, were followed to investigate the incidence of ASCVD. The baseline BP was classified into four categories: normal BP (BP1), high normal BP (BP2), elevated BP (BP3), and grade 1 hypertension (BP4) based on the 2019 Japanese Society of Hypertension guidelines.
Results: After an average 10.6 ± 2.6 years of follow-up, the multivariable hazard ratio for the development of ASCVD (n = 994) was already increased in medicated hypertensive patients with BP1 in comparison with untreated individuals with BP1; however, among medicated hypertensive patients, this risk was separated between the UAE groups, which were classified according to the median UACR (male, 15.4 mg/g; female, 19.0 mg/g). In medicated hypertensive patients with any category of BP1-BP3, the adjusted risk of the development of ASCVD in those with lower and higher UACRs was comparable to that observed in untreated individuals in the BP1 and BP4 categories, respectively.
Conclusion: In medicated patients with well controlled hypertension, UAE is useful for stratifying the residual risk of developing ASCVD in comparison to nonhypertensive individuals with optimal risk levels. |
| 抄録（URL） |
|
|
表示名 |
Utility of urinary albumin excretion as an index for stratifying the residual cardiovascular risk in patients undergoing antihypertensive agents treatment |
|
URL |
https://journals.lww.com/jhypertension/Fulltext/2021/12000/Utility_of_urinary_albumin_excretion_as_an_index.12.aspx |
| 出版者 |
|
|
出版者 |
Wolters Kluwer Health, Inc. |
| 権利 |
|
|
権利情報 |
© 2021 The Author(s). |
| 権利URI |
|
|
権利情報 |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
info:doi/10.1097/HJH.0000000000002947 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
jht-v39n12p2431-2438 (581.7 kB)
