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Supplementation with Dietary Leucine to a Protein-Deficient Diet Suppresses Myofibrillar Protein Degradation in Rats
https://iwate-u.repo.nii.ac.jp/records/9055
https://iwate-u.repo.nii.ac.jp/records/905543364494-10bc-40be-806c-c93f70760ff0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JNSV53_552.pdf (111.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-02-01 | |||||
| タイトル | ||||||
| タイトル | Supplementation with Dietary Leucine to a Protein-Deficient Diet Suppresses Myofibrillar Protein Degradation in Rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | myofibrillar | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | protein | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | degradation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | leucine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sarcopenia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | muscle protein metabolism | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
SUGAWARA, Takayuki
× SUGAWARA, Takayuki× ITO, Yoshiaki× NISHIZAWA, Naoyuki× NAGASAWA, Takashi |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 71442 | |||||
| 姓名 | 菅原, 貴征 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 71443 | |||||
| 姓名 | 伊藤, 芳明 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 71444 | |||||
| 姓名 | 西澤, 直行 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 71445 | |||||
| 姓名 | 長澤, 孝志 | |||||
| 著者(機関) | ||||||
| 値 | United Graduate School of Agricultural Sciences, Iwate University | |||||
| 著者(機関) | ||||||
| 値 | Biological Chemistry and Food Sciences, Faculty of Agriculture, Iwate University | |||||
| 著者(機関) | ||||||
| 値 | Biological Chemistry and Food Sciences, Faculty of Agriculture, Iwate University | |||||
| 著者(機関) | ||||||
| 値 | Biological Chemistry and Food Sciences, Faculty of Agriculture, Iwate University | |||||
| 登録日 | ||||||
| 日付 | 2008-02-01 | |||||
| 書誌情報 |
Journal of Nutritional Science and Vitaminology 巻 53, 号 6, p. 552-555, 発行日 2008-01-18 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0301-4800 | |||||
| Abstract | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Muscle mass is regulated by the synthesis and degradation of muscle protein, which in turn are affected by aging, several catabolic diseases, and malnutrition. Amino acids, particularly leucine, are known to stimulate muscle protein synthesis and suppress muscle protein degradation, although their long-term effects are unclear. The objective of our research was to elucidate whether long-term feeding of a protein-free or low-protein diet supplemented with leucine suppresses myofbrillar protein degradation. The rate of myofibrillar protein degradation was measured by the rate of release of 3-methylhistidine (MeHis) from isolated extensor digitorum longus (EDL) muscle. The weight of gastrocnemius muscle decreased in rats fed aprotein-free diet for 7 d; however, a leucine-supplemented (1.5%) diet tended to suppress this decrease. The release of MeHis from EDL muscle was increased by the protein-free diet and decreased by the feeding of a diet supplemented with leucine to the level of a 20% casein diet. When rats were fed a 5% casein diet, the gastrocnemius muscle weight decreased and MeHis release from EDL muscle increased compared to those fed a 20% casein diet. However, feeding of a 5% casein diet supplemented with leucine (1.15%) reduced muscle weight loss and MeHis release. These results suggest that long-term feeding of leucine suppresses the rate of myofibrillar protein degradation and muscle weight loss in rats fed a protein-deficient diet. | |||||
| 出版者 | ||||||
| 出版者 | 日本ビタミン学会 | |||||
| 権利 | ||||||
| 権利情報 | 日本ビタミン学会 | |||||
| 権利 | ||||||
| 権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00703822 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 異版である | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://ci.nii.ac.jp/naid/110006531878/ | |||||
