| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2010-10-05 |
| タイトル |
|
|
タイトル |
Differences in tyrosine hydroxylase expression after short-term hypoxia, hypercapnia or hypercapnic hypoxia in rat carotid body |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Respiratory reflex |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Hypoxia |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Hypercapnia |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Carotid body |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Tyrosine hydroxylase |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Chemoreception |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Wakai, Jun
Kizaki, Keiichiro
Yamaguchi-Yamada, Misuzu
Yamamoto, Yoshio
|
| 著者(機関) |
|
|
値 |
Laboratory of Veterinary Biochemistry and Cell Biology, Faculty of Agriculture, Iwate University, Department of Basic Veterinary Science, United Graduate School of Veterinary Science, Gifu University, Japan Society for the Promotion of Science (JSPS) |
| 著者(機関) |
|
|
値 |
Laboratory of Veterinary Physiology, Faculty of Agriculture, Iwate University, Department of Basic Veterinary Science, United Graduate School of Veterinary Science, Gifu University |
| 著者(機関) |
|
|
値 |
Laboratory of Veterinary Biochemistry and Cell Biology, Faculty of Agriculture, Iwate University, Department of Basic Veterinary Science, United Graduate School of Veterinary Science, Gifu University |
| 著者(機関) |
|
|
値 |
Laboratory of Veterinary Biochemistry and Cell Biology, Faculty of Agriculture, Iwate University, Department of Basic Veterinary Science, United Graduate School of Veterinary Science, Gifu University |
| 登録日 |
|
|
日付 |
2010-10-05 |
| 書誌情報 |
Respiratory Physiology & Neurobiology
巻 173,
号 1,
p. 95-100,
発行日 2010-08-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1569-9048 |
| Abstract |
|
|
内容記述タイプ |
Other |
|
内容記述 |
In the carotid body (CB), it has been reported that the expressions of tyrosine hydroxylase (TH) mRNA and TH protein are enhanced by exposure to hypoxia. However, it is not known whether CO_2 affects the expression of TH in the CB. We examined the expression of TH mRNA and the immunoreactivity for TH in the CB of rats exposed to hypoxia (10% O_2), hypercapnia (10% CO_2) and hypercapnic hypoxia (10% O_2 and 10% CO_2) for 2–24 h. The expression of TH mRNA in the CB was markedly enhanced in rats exposed to hypoxia for 4 h (6.6-fold), 6 h (6.0-fold) and 8 h (7.8-fold), and in rats exposed to hypercapnic hypoxia for 12 h (4.8-fold). The most intense TH immunoreactivity was observed in the CB from rats exposed to hypoxia for 12 and 24 h and to hypercapnic hypoxia for 24 h. The expressions of TH mRNA and the immunoreactivity for TH were not altered in the CB of rats exposed to hypercapnia. It is suggested that CO_2 does not affect TH expression in the CB, and that it inhibits hypoxia-enhanced TH expression. |
| 出版者 |
|
|
出版者 |
Elsevier B.V. |
| 権利 |
|
|
権利情報 |
(c) 2010 Elsevier B.V. |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.resp.2010.07.003 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
rpn-v173n1p95-100.pdf (271.1 kB)
