| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2011-09-14 |
| タイトル |
|
|
タイトル |
Oral administration of bovine lactoferrin upregulates neutrophil functions in a dog with familial β2-integrin-related neutrophil dysfunction |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Bovine lactoferrin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Integrins |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
CD11b/CD18 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Familial neutrophil dysfunction |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Superoxide production |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kobayashi, Saori
Abe, Yuya
Inanami, Osamu
Oda, Shinichi
Yamauchi, Koji
Hankanga, Careen
Yasuda, Jun
Sato, Reeko
|
| 著者(機関) |
|
|
値 |
Laboratory of Veterinary Small Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University |
| 著者(機関) |
|
|
値 |
Laboratory of Veterinary Small Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University |
| 著者(機関) |
|
|
値 |
Laboratory of Radiation Biology, Department of Environmental Veterinary Medical Sciences, Graduate School of Veterinary Medicine, Hokkaido University |
| 著者(機関) |
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|
値 |
Department of Animal Science, Faculty of Agriculture, Iwate University |
| 著者(機関) |
|
|
値 |
Food Science and Technology Institute, Morinaga Milk Industry Co., Ltd |
| 著者(機関) |
|
|
値 |
Laboratory of Veterinary Small Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University |
| 著者(機関) |
|
|
値 |
Laboratory of Veterinary Small Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University |
| 著者(機関) |
|
|
値 |
Laboratory of Veterinary Small Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University |
| 登録日 |
|
|
日付 |
2011-09-14 |
| 書誌情報 |
Veterinary Immunology and Immunopathology
巻 143,
号 1-2,
p. 155-161,
発行日 2011-09-15
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0165-2427 |
| Abstract |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Lactoferrin, a glycoprotein present in neutrophils and exocrine secretions, plays important roles in host defense. Administration of bovine lactoferrin has been reported to modulate various neutrophil functions. We found a mixed-breed male dog with novel familial neutrophil dysfunction. The disorder was caused by a decrease of β2-integrin expression encoding CD18 without mutation. Antibiotics therapy alone did not influence a series of neutrophil functions in the same dog. We examined the effects of oral administration of bovine lactoferrin on the neutrophil function and clinical symptoms in the same dog. Oral chronic administration of bovine lactoferrin increased neutrophilic β2-integrin gene expression comparable to normal dogs, followed by the upregulation of surface CD18 expression. Concurrently, the superoxide production, phagocytic activity and adherence that were β2-integrin-related neutrophil functions increased to normal canine levels. The chronic inflammation from bacterial upper respiratory infections and pneumonia was also alleviated in the dog. Our results indicate that oral treatment with bovine lactoferrin increases neutrophil β2-integrin transcript level, leading to the upregulation of neutrophil functions and improvement of clinical symptoms in the dog with familial neutrophil dysfunction. |
| 出版者 |
|
|
出版者 |
Elsevier B.V. |
| 権利 |
|
|
権利情報 |
Copyright © 2011 Elsevier B.V. |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.vetimm.2011.05.027 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
vii-v143i1-2p155-161.pdf (272.8 kB)
