Department of Veterinary Medicine, Faculty of Agriculture, Iwate University,
Department of Food Safety, Pharmaceutical and Medical Safety Bureau, Ministry of Health, Labour and Welfare
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University,
Department of Environmental and Occupational Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University,
Sciences of Cryobiosystems, United Graduate School of Agricultural Sciences of Iwate University
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
登録日
2012-10-09
雑誌名
Advances in Pharmacological Sciences
巻
2012
ページ
708178(1) - 708178(5)
発行年
2012-01-01
ISSN
1687-6334
Abstract
Anticholinesterases (antiChEs) are used to treat Alzheimer’s disease. The comparative effects of two antiChEs, methanesulfonyl fluoride (MSF) and donepezil, on the extracellular levels of ACh in the hippocampus were investigated by in vivo microdialysis in freely moving rats. MSF at 1 and 2 mg/kg produced a dose-dependent increase in ACh efflux from 10 min to at least 3 hrs after injection. At 2 mg/kg, the increase was still present at 24 hr. Donepezil at 1 mg/kg showed a similar but smaller effect, and, paradoxically, 2 mg/kg showed no consistent effect. MSF at 1 and 2 mg/kg decreased acetylcholinesterase activity in the hippocampus to 54.8 and 20.1% of control, respectively. These results suggest that MSF is a suitable candidate for the treatment of Alzheimer’s disease.
Effect of a CNS-Sensitive Anticholinesterase Methane Sulfonyl Fluoride on Hippocampal Acetylcholine Release in Freely Moving Rats
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