| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2012-10-09 |
| タイトル |
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|
タイトル |
Effect of a CNS-Sensitive Anticholinesterase Methane Sulfonyl Fluoride on Hippocampal Acetylcholine Release in Freely Moving Rats |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Imanishi, Tamotsu
Hossain, Muhammad Mubarak
Suzuki, Tadahiko
Xu, Ping
Sato, Itaru
Kobayashi, Haruo
|
| 著者(機関) |
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|
値 |
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University,
Department of Food Safety, Pharmaceutical and Medical Safety Bureau, Ministry of Health, Labour and Welfare |
| 著者(機関) |
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|
値 |
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University,
Department of Environmental and Occupational Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey |
| 著者(機関) |
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|
値 |
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University |
| 著者(機関) |
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|
値 |
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University,
Sciences of Cryobiosystems, United Graduate School of Agricultural Sciences of Iwate University |
| 著者(機関) |
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値 |
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University |
| 著者(機関) |
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値 |
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University |
| 登録日 |
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|
日付 |
2012-10-09 |
| 書誌情報 |
Advances in Pharmacological Sciences
巻 2012,
p. 708178(1)-708178(5),
発行日 2012-01-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1687-6334 |
| Abstract |
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内容記述タイプ |
Other |
|
内容記述 |
Anticholinesterases (antiChEs) are used to treat Alzheimer’s disease. The comparative effects of two antiChEs, methanesulfonyl fluoride (MSF) and donepezil, on the extracellular levels of ACh in the hippocampus were investigated by in vivo microdialysis in freely moving rats. MSF at 1 and 2 mg/kg produced a dose-dependent increase in ACh efflux from 10 min to at least 3 hrs after injection. At 2 mg/kg, the increase was still present at 24 hr. Donepezil at 1 mg/kg showed a similar but smaller effect, and, paradoxically, 2 mg/kg showed no consistent effect. MSF at 1 and 2 mg/kg decreased acetylcholinesterase activity in the hippocampus to 54.8 and 20.1% of control, respectively. These results suggest that MSF is a suitable candidate for the treatment of Alzheimer’s disease. |
| 出版者 |
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|
出版者 |
Hindawi Publishing Corporation |
| 権利 |
|
|
権利情報 |
Copyright © 2012 Tamotsu Imanishi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1155/2012/708178 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
aps-v2012p708178.pdf (656.5 kB)
