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層状複水酸化物のドラッグデリバリー材料としての応用
https://iwate-u.repo.nii.ac.jp/records/10338
https://iwate-u.repo.nii.ac.jp/records/1033823d89f64-894a-41a4-819c-2b2e6b726a93
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
nk-v48n3p137-144.pdf (3.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2014-09-08 | |||||||
| タイトル | ||||||||
| タイトル | 層状複水酸化物のドラッグデリバリー材料としての応用 | |||||||
| 言語 | ||||||||
| 言語 | jpn | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Layered double hydroxide | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Intercalation | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Anticancer drug | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Peptide | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Cytotoxicity | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 著者 |
會澤, 純雄
× 會澤, 純雄
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| 著者別名 | ||||||||
| 識別子Scheme | WEKO | |||||||
| 識別子 | 64090 | |||||||
| 姓名 | AISAWA, Sumio | |||||||
| 著者(機関) | ||||||||
| 値 | 岩手大学大学院工学研究科 | |||||||
| 登録日 | ||||||||
| 日付 | 2014-09-08 | |||||||
| 書誌情報 |
粘土科学 巻 49, 号 3, p. 75-81, 発行日 2011-01-01 |
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| Abstract | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Layered double hydroxide (LDH) is widely known as anionic clay, host-guest material and anion-exchanger. LDH is a class of nanomaterials that have attracted considerable attention for their potential utility as material for drug and biomolecule delivery. In this study, the intercalation behavior of anticancer drug (5-fluorouracil: 5-FU), the synthesis of 5-FU/Mg-Al LDH and peptide modified 5-FU/LDH (peptide/5-FU/LDH) have been investigated. Moreover, the cytotoxicity assay of the both LDHs for mammalian cells has also been studied. The 5-FU/LDH was characterized by various techniques such as XRD and FT-IR that demonstrated the intercalation of 5-FU into the LDH by using coprecipitation and ion exchange methods. Then, the surface of the 5-FU/LDH was modified with collagen and soy bean peptides. After the modification, the peptide/5-FU/LDH maintained its original LDH structure. The results of cytotoxicity assay for mammalian cells showed that the 5-FU/LDH and the peptide/5-FU/LDH have 1.9 and 7.7 times better drug efficacy than naked 5-FU. The peptide/5-FU/LDH exhibited a quick cytotoxic effect compared with the 5-FU/LDH. The present results suggest that LDH and the peptide modified LDH have the great potential of the materials for drug delivery. |
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| 出版者 | ||||||||
| 出版者 | 日本粘土学会 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | Application of layered double hydroxides as material for drug delivery | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
