| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-12-16 |
| タイトル |
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タイトル |
Near-infrared (NIR) up-conversion optogenetics |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
HOSOSHIMA, Shoko
YUASA, Hideya
ISHIZUKA, Toru
Mohammad Razuanul Hoque
YAMASHITA, Takayuki
YAMANAKA, Akihiro
SUGANO, Eriko
TOMITA, Hiroshi
YAWO, Hiromu
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| 著者(機関) |
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|
値 |
Department of Developmental Biology and Neuroscience, Tohoku University Graduate School of Life Sciences |
| 著者(機関) |
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値 |
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology |
| 著者(機関) |
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値 |
Department of Developmental Biology and Neuroscience, Tohoku University Graduate School of Life Sciences |
| 著者(機関) |
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値 |
Department of Developmental Biology and Neuroscience, Tohoku University Graduate School of Life Sciences |
| 著者(機関) |
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値 |
Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University |
| 著者(機関) |
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値 |
Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University |
| 著者(機関) |
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値 |
Laboratory of Visual Neuroscience, Department of Chemistry and Bioengineering, Iwate University Graduate School of Engineering |
| 著者(機関) |
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値 |
Laboratory of Visual Neuroscience, Department of Chemistry and Bioengineering, Iwate University Graduate School of Engineering, Clinical Research, Innovation and Education Center, Tohoku University Hospital |
| 著者(機関) |
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値 |
Department of Developmental Biology and Neuroscience, Tohoku University Graduate School of Life Sciences, Center for Neuroscience, Tohoku University Graduate School of Medicine |
| 登録日 |
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日付 |
2021-12-16 |
| 書誌情報 |
Scientific Reports
巻 5,
p. 16533,
発行日 2015-11-10
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
20452322 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Non-invasive remote control technologies designed to manipulate neural functions have been long-awaited for the comprehensive and quantitative understanding of neuronal network in the brain as well as for the therapy of neurological disorders. Recently, it has become possible for the neuronal activity to be optically manipulated using biological photo-reactive molecules such as channelrhodopsin (ChR)-2. However, ChR2 and its relatives are mostly reactive to visible light, which does not effectively penetrate through biological tissues. In contrast, near-infrared (NIR) light (650–1450 nm) penetrates deep into the tissues because biological systems are almost transparent to light within this so-called ‘imaging window’. Here we used lanthanide nanoparticles (LNPs), composed of rare-earth elements, as luminous bodies to activate ChRs since they absorb low-energy NIR light to emit high-energy visible light (up-conversion). Here, we created a new type of optogenetic system which consists of the donor LNPs and the acceptor ChRs. The NIR laser irradiation emitted visible light from LNPs, then induced the photo-reactive responses in the near-by cells that expressed ChRs. However, there remains room for large improvements in the energy efficiency of the LNP-ChR system. |
| 出版者 |
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出版者 |
Springer Nature |
| 関係URI |
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識別子タイプ |
URI |
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関連識別子 |
https://www.nature.com/articles/srep16533 |
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関連名称 |
Near-infrared (NIR) up-conversion optogenetics |
| 権利URI |
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権利情報 |
http://creativecommons.org/licenses/by/4.0/ |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
info:doi/10.1038/srep16533 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
sr-v5p16553 (3.0 MB)
