| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-01-22 |
| タイトル |
|
|
タイトル |
α2-Adrenergic Modulation of Glucagon and Insulin Secretions in Sheep |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
clonidine |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
midaglizole |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
yohimbine |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
glucagon |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
insulin |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
ODA, SHINICHI
FUJIMURA, HIDEAKI
SASAKI, YASUYUKI
OHNEDA, AKIRA
|
| 著者(機関) |
|
|
値 |
Laboratory of Animal Physiology, Faculty of Agriculture,Tohoku University |
| 著者(機関) |
|
|
値 |
Laboratory of Animal Physiology, Faculty of Agriculture, Tohoku University |
| 著者(機関) |
|
|
値 |
Laboratory of Animal Physiology, Faculty of Agriculture,Tohoku University |
| 著者(機関) |
|
|
値 |
Health Center, Tohoku University |
| 登録日 |
|
|
日付 |
2009-01-22 |
| 書誌情報 |
The Tohoku Journal of Experimental Medicine
巻 163,
号 2,
p. 101-110,
発行日 1991-01-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0040-8727 |
| Abstract |
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|
内容記述タイプ |
Other |
|
内容記述 |
ODA, S., FUJIMURA, H., SASAKI, Y, and OHNEDA, A. α2-Adrenergic Modulation of Glucagon and Insulin Secretions in Sheep. Tohoku J. Exp. Med., 1991, 163 (2), 101-110 - To investigate the effects of α2-adrenergic receptors on the secretions of pancreatic glucagon and insulin, clonidine, midaglizole and yohimbine were intravenously administered in four conscious sheep. Clonidine infusion at a dosage of 1.0nmol/kg/min produced hyperglucagonemia, hypoinsulinemia and hyperglycemia. Midaglizole or yohimbine was infused for 30min, at doses of 5, 10 and 50nmol/kg/min during the clonidine infusion. The highest yohimbine infusion (50nmol/kg/min) blocked the clonidine-induced responses of glucagon, insulin and glucose. On the other hand, the midaglizole (50nmol/kg/min) infusion brought about no statistical effect on the clonidine-induced responses of glucagon, insulin and glucose. The α2-adrenergic antagonistic effect of midaglizole was clearly less than that of yohimbine in the present experiments. It is concluded that the glucagon secretion is enhanced and the insulin release is inhibited by α2-adrenergic stimulation in conscious sheep. |
| 出版者 |
|
|
出版者 |
東北ジャーナル刊行会 |
| 権利 |
|
|
権利情報 |
© 東北ジャーナル刊行会 |
| 権利 |
|
|
権利情報 |
©J-STAGE |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1620/tjem.163.101 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
tjem-v163n2p101-110.pdf (1.0 MB)
