| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-12-07 |
| タイトル |
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タイトル |
Multicoding in neural information transfer suggested by mathematical analysis of the frequency‑dependent synaptic plasticity in vivo |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
HATA, Katsuhiko
ARAKI, Osamu
YOKOI, Osamu
KUSAKABE, Tatsumi
YAMAMOTO, Yoshio
ITO, Susumu
NIKUNI, Tetsuro
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| 著者(機関) |
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|
値 |
Department of Sports and Medical Science, Kokushikan University, Department of Neuroscience, Research Center for Mathematical Medicine, Department of Physics, Faculty of Science Division I, Tokyo University of Science |
| 著者(機関) |
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値 |
Department of Applied Physics, Faculty of Science Division I, Tokyo University of Science |
| 著者(機関) |
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値 |
Department of Neuroscience, Research Center for Mathematical Medicine |
| 著者(機関) |
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値 |
Department of Sports and Medical Science, Kokushikan University |
| 著者(機関) |
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値 |
Laboratory of Veterinary Biochemistry and Cell Biology, Faculty of Agriculture, Iwate University |
| 著者(機関) |
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値 |
Department of Sports and Medical Science, Kokushikan University |
| 著者(機関) |
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値 |
Department of Physics, Faculty of Science Division I, Tokyo University of Science |
| 書誌情報 |
Scientific Reports
巻 10,
p. 13974,
発行日 2020-08-18
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
20452322 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Two elements of neural information processing have primarily been proposed: firing rate and spike timing of neurons. In the case of synaptic plasticity, although spike-timing-dependent plasticity (STDP) depending on presynaptic and postsynaptic spike times had been considered the most common rule, recent studies have shown the inhibitory nature of the brain in vivo for precise spike timing, which is key to the STDP. Thus, the importance of the firing frequency in synaptic plasticity in vivo has been recognized again. However, little is understood about how the frequency-dependent synaptic plasticity (FDP) is regulated in vivo. Here, we focused on the presynaptic input pattern, the intracellular calcium decay time constants, and the background synaptic activity, which vary depending on neuron types and the anatomical and physiological environment in the brain. By analyzing a calcium-based model, we found that the synaptic weight differs depending on these factors characteristic in vivo, even if neurons receive the same input rate. This finding suggests the involvement of multifaceted factors other than input frequency in FDP and even neural coding in vivo. |
| 出版者 |
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出版者 |
Springer Nature |
| 関係URI |
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識別子タイプ |
URI |
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関連識別子 |
https://www.nature.com/articles/s41598-020-70876-4#Sec1 |
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関連名称 |
Multicoding in neural information transfer suggested by mathematical analysis of the frequency‑dependent synaptic plasticity in vivo |
| 権利 |
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権利情報 |
© The Author(s) 2020 |
| 権利URI |
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権利情報 |
http://creativecommons.org/licenses/by/4.0/ |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
info:doi/10.1038/s41598-020-70876-4 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
sr-v10p13974 (2.5 MB)
