| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2014-05-28 |
| タイトル |
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タイトル |
Effect of Peripheral 5-HT on Glucose and Lipid Metabolism in Wether Sheep |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Watanabe, Hitoshi
Saito, Ryo
Nakano, Tatsuya
Takahashi, Hideyuki
Takahashi, Yu
Sumiyoshi, Keisuke
Sato, Katsuyoshi
Chen, Xiangning
Okada, Natsumi
Iwasaki, Shunsuke
Harjanti, Dian W.
Sekiguchi, Natsumi
Sano, Hiroaki
Kitazawa, Haruki
Rose, Michael T.
Ohwada, Shyuichi
Watanabe, Kouichi
Aso, Hisashi
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| 著者(機関) |
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|
値 |
Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University |
| 著者(機関) |
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値 |
Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University |
| 著者(機関) |
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|
値 |
Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University |
| 著者(機関) |
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|
値 |
Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University |
| 著者(機関) |
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|
値 |
Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University |
| 著者(機関) |
|
|
値 |
Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University |
| 著者(機関) |
|
|
値 |
Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University |
| 著者(機関) |
|
|
値 |
Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University |
| 著者(機関) |
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値 |
Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University |
| 著者(機関) |
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値 |
Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University |
| 著者(機関) |
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|
値 |
Department of Animal Sciences, Faculty of Agriculture, Iwate University |
| 著者(機関) |
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値 |
Department of Animal Sciences, Faculty of Agriculture, Iwate University |
| 著者(機関) |
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値 |
Department of Animal Sciences, Faculty of Agriculture, Iwate University |
| 著者(機関) |
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|
値 |
Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University |
| 著者(機関) |
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値 |
Institute of Biological, Environmental and Rural Sciences, Aberystwyth University |
| 著者(機関) |
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|
値 |
Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University |
| 著者(機関) |
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|
値 |
Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University |
| 著者(機関) |
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|
値 |
Cellar Biology Laboratory, Graduate School of Agricultural Science, Tohoku University |
| 登録日 |
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|
日付 |
2014-05-28 |
| 書誌情報 |
PLOS ONE
巻 9,
号 2,
p. e88058,
発行日 2014-02-01
|
| Abstract |
|
|
内容記述タイプ |
Other |
|
内容記述 |
In mice, peripheral 5-HT induces an increase in the plasma concentrations of glucose, insulin and bile acids, and a decrease
in plasma triglyceride, NEFA and cholesterol concentrations. However, given the unique characteristics of the metabolism of
ruminants relative to monogastric animals, the physiological role of peripheral 5-HT on glucose and lipid metabolism in
sheep remains to be established. Therefore, in this study, we investigated the effect of 5-HT on the circulating
concentrations of metabolites and insulin using five 5-HT receptor (5HTR) antagonists in sheep. After fasting for 24 h, sheep
were intravenously injected with 5-HT, following which-, plasma glucose, insulin, triglyceride and NEFA concentrations were
significantly elevated. In contrast, 5-HT did not affect the plasma cholesterol concentration, and it induced a decrease in bile
acid concentrations. Increases in plasma glucose and insulin concentrations induced by 5-HT were attenuated by pretreatment
with Methysergide, a 5HTR 1, 2 and 7 antagonist. Additionally, decreased plasma bile acid concentrations induced
by 5-HT were blocked by pre-treatment with Ketanserin, a 5HTR 2A antagonist. However, none of the 5HTR antagonists
inhibited the increase in plasma triglyceride and NEFA levels induced by 5-HT. On the other hand, mRNA expressions of
5HTR1D and 1E were observed in the liver, pancreas and skeletal muscle. These results suggest that there are a number of
differences in the physiological functions of peripheral 5-HT with respect to lipid metabolism between mice and sheep,
though its effect on glucose metabolism appears to be similar between these species. |
| 出版者 |
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出版者 |
Public Library of Science |
| 権利 |
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|
権利情報 |
©2014 Watanabe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1371/journal.pone.0088058 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
ploso-v9i2pe88058.pdf (1.0 MB)
