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In vivo calcium imaging of OFF-responding ASK chemosensory neurons in C. elegans
https://iwate-u.repo.nii.ac.jp/records/9784
https://iwate-u.repo.nii.ac.jp/records/978411983c1e-8d33-4b16-bc77-3f2d7b11998e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
bbags-v1790i8p765-769.pdf (724.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2009-09-17 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | In vivo calcium imaging of OFF-responding ASK chemosensory neurons in C. elegans | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | G-CaMP | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | calcium imaging | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | imaging | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | sensory neuron | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | OFF-response | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | L-lysine | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | SDS | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 著者 |
Wakabayashi, Tokumitsu
× Wakabayashi, Tokumitsu
× Kimura, Yukihiro
× Ohba, Yusuke
× Adachi, Ryota
× Satoh, Yoh-ichi
× Shingai, Ryuzo
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| 著者(機関) | ||||||||||||||||||
| 値 | Laboratory of Bioscience, Faculty of Engineering, Iwate University | |||||||||||||||||
| 著者(機関) | ||||||||||||||||||
| 値 | Laboratory of Bioscience, Faculty of Engineering, Iwate University | |||||||||||||||||
| 著者(機関) | ||||||||||||||||||
| 値 | Laboratory of Bioscience, Faculty of Engineering, Iwate University | |||||||||||||||||
| 著者(機関) | ||||||||||||||||||
| 値 | Laboratory of Bioscience, Faculty of Engineering, Iwate University | |||||||||||||||||
| 著者(機関) | ||||||||||||||||||
| 値 | Department of Cell Biology and Functional Morphology, Iwate Medical University | |||||||||||||||||
| 著者(機関) | ||||||||||||||||||
| 値 | Laboratory of Bioscience, Faculty of Engineering, Iwate University | |||||||||||||||||
| 登録日 | ||||||||||||||||||
| 日付 | 2009-09-17 | |||||||||||||||||
| 書誌情報 |
Biochimica et Biophysica Acta (BBA) - General Subjects 巻 1790, 号 8, p. 765-769, 発行日 2009-01-01 |
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| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 0304-4165 | |||||||||||||||||
| Abstract | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | Background: How neurons and neuronal circuits transform sensory input into behavior is not well understood. Because of its well-described, simple nervous system, Caenorhabditis elegans is an ideal model organism to study this issue. Transformation of sensory signals into neural activity is a crucial first step in the sensory–motor transformation pathway in an animal's nervous system. We examined the properties of chemosensory ASK neurons of C. elegans during sensory stimulation. Method: A genetically encoded calcium sensor protein, G-CaMP, was expressed in ASK neurons of C. elegans, and the intracellular calcium dynamics of the neurons were observed. Results: After application of the attractants L-lysine or food-related stimuli, the level of calcium in ASK neurons decreased. In contrast, responses increased upon stimulus removal. Opposite responses were observed after application and removal of a repellent. Conclusion: The observed changes in response to external stimuli suggest that the activity of ASK neurons may impact stimulus-evoked worm behavior. The stimulus-ON/activity-OFF properties of ASK neurons are similar to those of vertebrate retinal photoreceptors. General significance: Analysis of sensory–motor transformation pathways based on the activity and structure of neuronal circuits is an important goal in neurobiology and is practical in C. elegans. Our study provides insights into the mechanism of such transformation in the animal. |
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| 出版者 | ||||||||||||||||||
| 出版者 | IEEE | |||||||||||||||||
| 権利 | ||||||||||||||||||
| 権利情報 | © 2009 Elsevier B.V. | |||||||||||||||||
| DOI | ||||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | 10.1016/j.bbagen.2009.03.032 | |||||||||||||||||
| 著者版フラグ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
